Cargando…

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

We report detailed susceptibility profiling of asexual blood stages of the malaria parasite Plasmodium falciparum to clinical and experimental antimalarials, combined with metabolomic fingerprinting. Results revealed a variety of stage-specific and metabolic profiles that differentiated the modes of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murithi, James M., Owen, Edward S., Istvan, Eva S., Lee, Marcus C.S., Ottilie, Sabine, Chibale, Kelly, Goldberg, Daniel E., Winzeler, Elizabeth A., Llinás, Manuel, Fidock, David A., Vanaerschot, Manu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031696/ https://www.ncbi.nlm.nih.gov/pubmed/31813848 http://dx.doi.org/10.1016/j.chembiol.2019.11.009

Ejemplares similares

Antimalarial drug discovery: progress and approaches
por: Siqueira-Neto, Jair L, et al.
Publicado: (2023)

Prioritization of Molecular Targets for Antimalarial Drug Discovery
por: Forte, Barbara, et al.
Publicado: (2021)

Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
por: Luth, Madeline R., et al.
Publicado: (2018)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
por: Antonova-Koch, Yevgeniya, et al.
Publicado: (2018)

MalDA, Accelerating Malaria Drug Discovery
por: Yang, Tuo, et al.
Publicado: (2021)

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
por: Vanaerschot, Manu, et al.
Publicado: (2020)

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
por: Murithi, James M., et al.
Publicado: (2022)

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials
por: Abraham, Matthew, et al.
Publicado: (2020)

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates
por: Okombo, John, et al.
Publicado: (2018)

Metallocene Antimalarials: The Continuing Quest
por: Blackie, Margaret A. L., et al.
Publicado: (2008)

The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957
por: Miguel-Blanco, Celia, et al.
Publicado: (2021)

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
por: Reader, Janette, et al.
Publicado: (2021)

Esterase mutation is a mechanism of resistance to antimalarial compounds
por: Istvan, Eva S., et al.
Publicado: (2017)

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum
por: Rocamora, Frances, et al.
Publicado: (2021)

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
por: Stokes, Barbara H., et al.
Publicado: (2019)

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
por: Summers, Robert L., et al.
Publicado: (2022)

The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa
por: Winzeler, Elizabeth A., et al.
Publicado: (2019)

Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies
por: Singh, Kamaljit, et al.
Publicado: (2013)

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
por: LaMonte, Gregory M., et al.
Publicado: (2020)

Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach
por: Ahmad, Siti Junaidah, et al.
Publicado: (2017)

Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity
por: Sullivan, David J., et al.
Publicado: (2015)

The genomic architecture of antimalarial drug resistance
por: Cowell, Annie N, et al.
Publicado: (2019)

A Pharmacokinetic Study of Antimalarial 3,5-Diaryl-2-aminopyridine Derivatives
por: Dambuza, Ntokozo, et al.
Publicado: (2015)

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery
por: Shibeshi, Melkamu Adigo, et al.
Publicado: (2020)

Drug resistance genomics of the antimalarial drug artemisinin
por: Winzeler, Elizabeth A, et al.
Publicado: (2014)

Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies
por: Attram, Henrietta D., et al.
Publicado: (2023)

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
por: Cowell, Annie N., et al.
Publicado: (2018)

The antimalarial resistome – finding new drug targets and their modes of action
por: Carolino, Krypton, et al.
Publicado: (2020)

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis
por: Istvan, Eva S, et al.
Publicado: (2019)

Anticancer Properties of Distinct Antimalarial Drug Classes
por: Hooft van Huijsduijnen, Rob, et al.
Publicado: (2013)

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids
por: Viira, Birgit, et al.
Publicado: (2016)

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery
por: Okombo, John, et al.
Publicado: (2017)

Propensity of selecting mutant parasites for the antimalarial drug cabamiquine
por: Stadler, Eva, et al.
Publicado: (2023)

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone
por: Skinner-Adams, Tina S., et al.
Publicado: (2019)

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials
por: Murugesan, Dinakaran, et al.
Publicado: (2013)

Antimalarial drug discovery – the path towards eradication
por: BURROWS, JEREMY N, et al.
Publicado: (2014)

Discovery and optimisation studies of antimalarial phenotypic hits
por: Mital, Alka, et al.
Publicado: (2015)

A Biosynthetic Platform for Antimalarial Drug Discovery
por: Wilkinson, Mark D., et al.
Publicado: (2020)

The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites
por: Delves, Michael, et al.
Publicado: (2012)

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
por: Dorjsuren, Dorjbal, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dpvru41oo94gufulaeng6dtr99