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The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia

BACKGROUND: In recent years, Ecuador and other South American countries have experienced an increase in arboviral diseases. A rise in dengue infections was followed by introductions of chikungunya and Zika, two viruses never before seen in many of these areas. Furthermore, the latest socioeconomic a...

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Autores principales: Maljkovic Berry, Irina, Rutvisuttinunt, Wiriya, Sippy, Rachel, Beltran-Ayala, Efrain, Figueroa, Katherine, Ryan, Sadie, Srikanth, Abhinaya, Stewart-Ibarra, Anna M., Endy, Timothy, Jarman, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031975/
https://www.ncbi.nlm.nih.gov/pubmed/32075576
http://dx.doi.org/10.1186/s12862-020-1596-8
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author Maljkovic Berry, Irina
Rutvisuttinunt, Wiriya
Sippy, Rachel
Beltran-Ayala, Efrain
Figueroa, Katherine
Ryan, Sadie
Srikanth, Abhinaya
Stewart-Ibarra, Anna M.
Endy, Timothy
Jarman, Richard G.
author_facet Maljkovic Berry, Irina
Rutvisuttinunt, Wiriya
Sippy, Rachel
Beltran-Ayala, Efrain
Figueroa, Katherine
Ryan, Sadie
Srikanth, Abhinaya
Stewart-Ibarra, Anna M.
Endy, Timothy
Jarman, Richard G.
author_sort Maljkovic Berry, Irina
collection PubMed
description BACKGROUND: In recent years, Ecuador and other South American countries have experienced an increase in arboviral diseases. A rise in dengue infections was followed by introductions of chikungunya and Zika, two viruses never before seen in many of these areas. Furthermore, the latest socioeconomic and political instability in Venezuela and the mass migration of its population into the neighboring countries has given rise to concerns of infectious disease spillover and escalation of arboviral spread in the region. RESULTS: We performed phylogeographic analyses of dengue (DENV) and chikungunya (CHIKV) virus genomes sampled from a surveillance site in Ecuador in 2014–2015, along with genomes from the surrounding countries. Our results revealed at least two introductions of DENV, in 2011 and late 2013, that initially originated from Venezuela and/or Colombia. The introductions were subsequent to increases in the influx of Venezuelan and Colombian citizens into Ecuador, which in 2013 were 343% and 214% higher than in 2009, respectively. However, we show that Venezuela has historically been an important source of DENV dispersal in this region, even before the massive exodus of its population, suggesting already established paths of viral distribution. Like DENV, CHIKV was introduced into Ecuador at multiple time points in 2013–2014, but unlike DENV, these introductions were associated with the Caribbean. Our findings indicated no direct CHIKV connection between Ecuador, Colombia, and Venezuela as of 2015, suggesting that CHIKV was, at this point, not following the paths of DENV spread. CONCLUSION: Our results reveal that Ecuador is vulnerable to arbovirus import from many geographic locations, emphasizing the need of continued surveillance and more diversified prevention strategies. Importantly, increase in human movement along established paths of viral dissemination, combined with regional outbreaks and epidemics, may facilitate viral spread and lead to novel virus introductions. Thus, strengthening infectious disease surveillance and control along migration routes and improving access to healthcare for the vulnerable populations is of utmost importance.
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spelling pubmed-70319752020-02-25 The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia Maljkovic Berry, Irina Rutvisuttinunt, Wiriya Sippy, Rachel Beltran-Ayala, Efrain Figueroa, Katherine Ryan, Sadie Srikanth, Abhinaya Stewart-Ibarra, Anna M. Endy, Timothy Jarman, Richard G. BMC Evol Biol Research Article BACKGROUND: In recent years, Ecuador and other South American countries have experienced an increase in arboviral diseases. A rise in dengue infections was followed by introductions of chikungunya and Zika, two viruses never before seen in many of these areas. Furthermore, the latest socioeconomic and political instability in Venezuela and the mass migration of its population into the neighboring countries has given rise to concerns of infectious disease spillover and escalation of arboviral spread in the region. RESULTS: We performed phylogeographic analyses of dengue (DENV) and chikungunya (CHIKV) virus genomes sampled from a surveillance site in Ecuador in 2014–2015, along with genomes from the surrounding countries. Our results revealed at least two introductions of DENV, in 2011 and late 2013, that initially originated from Venezuela and/or Colombia. The introductions were subsequent to increases in the influx of Venezuelan and Colombian citizens into Ecuador, which in 2013 were 343% and 214% higher than in 2009, respectively. However, we show that Venezuela has historically been an important source of DENV dispersal in this region, even before the massive exodus of its population, suggesting already established paths of viral distribution. Like DENV, CHIKV was introduced into Ecuador at multiple time points in 2013–2014, but unlike DENV, these introductions were associated with the Caribbean. Our findings indicated no direct CHIKV connection between Ecuador, Colombia, and Venezuela as of 2015, suggesting that CHIKV was, at this point, not following the paths of DENV spread. CONCLUSION: Our results reveal that Ecuador is vulnerable to arbovirus import from many geographic locations, emphasizing the need of continued surveillance and more diversified prevention strategies. Importantly, increase in human movement along established paths of viral dissemination, combined with regional outbreaks and epidemics, may facilitate viral spread and lead to novel virus introductions. Thus, strengthening infectious disease surveillance and control along migration routes and improving access to healthcare for the vulnerable populations is of utmost importance. BioMed Central 2020-02-19 /pmc/articles/PMC7031975/ /pubmed/32075576 http://dx.doi.org/10.1186/s12862-020-1596-8 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Maljkovic Berry, Irina
Rutvisuttinunt, Wiriya
Sippy, Rachel
Beltran-Ayala, Efrain
Figueroa, Katherine
Ryan, Sadie
Srikanth, Abhinaya
Stewart-Ibarra, Anna M.
Endy, Timothy
Jarman, Richard G.
The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia
title The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia
title_full The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia
title_fullStr The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia
title_full_unstemmed The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia
title_short The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia
title_sort origins of dengue and chikungunya viruses in ecuador following increased migration from venezuela and colombia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031975/
https://www.ncbi.nlm.nih.gov/pubmed/32075576
http://dx.doi.org/10.1186/s12862-020-1596-8
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