ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

BACKGROUND: Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. METHODS: MDA-MB-231 ce...

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Detalles Bibliográficos
Autores principales: Hu, Jinjiao, Zhang, Hongwei, Li, Jie, Jiang, Xiuxing, Zhang, Yanhao, Wu, Qin, Shen, liwen, Shi, Jingshan, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031977/
https://www.ncbi.nlm.nih.gov/pubmed/32075676
http://dx.doi.org/10.1186/s13046-020-01545-7

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