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Novel kidney injury biomarkers in tropical infections: a review of the literature
Tropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto de Medicina Tropical
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032010/ https://www.ncbi.nlm.nih.gov/pubmed/32074217 http://dx.doi.org/10.1590/S1678-9946202062014 |
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author | Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Tôrres, Paulo Pacelli Bezerra Filizola de Castro, Valeska Queiroz Lopes, Renata Lima Martins, Alice Maria Costa Daher, Elizabeth De Francesco |
author_facet | Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Tôrres, Paulo Pacelli Bezerra Filizola de Castro, Valeska Queiroz Lopes, Renata Lima Martins, Alice Maria Costa Daher, Elizabeth De Francesco |
author_sort | Meneses, Gdayllon Cavalcante |
collection | PubMed |
description | Tropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associated with increased patients’ morbidity and mortality. In most countries, kidney disease associated to tropical diseases is attended at health services with poor infrastructure and inadequate preventive measures. The long-term impacts of these infections on kidney tissue may be a main cause of future kidney disease in these patients. Therefore, the investigation of novel kidney injury biomarkers in these tropical diseases is of utmost importance to explain the mechanisms of kidney injury, to improve their diagnosis and prognosis, as well as the assessment to health systems by these patients. Since 2011, our group has been studying renal biomarkers in visceral and cutaneous leishmaniasis, schistosomiasis, leptospirosis and leprosy. This study has increased the knowledge on the pathophysiology of kidney disease in the presence of these infections and has contributed to the early diagnosis of kidney injury, pointing to glomerular, endothelial and inflammatory involvement as the main causes of the mechanisms leading to nephropathy and clinical complications. Future perspectives comprise establishing long-term cohort groups to assess the development of kidney disease and the patients’ survival, as well as the use of new biomarkers such as urinary exosomes to detect risk groups and to understand the progression of kidney injuries. |
format | Online Article Text |
id | pubmed-7032010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Instituto de Medicina Tropical |
record_format | MEDLINE/PubMed |
spelling | pubmed-70320102020-03-03 Novel kidney injury biomarkers in tropical infections: a review of the literature Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Tôrres, Paulo Pacelli Bezerra Filizola de Castro, Valeska Queiroz Lopes, Renata Lima Martins, Alice Maria Costa Daher, Elizabeth De Francesco Rev Inst Med Trop Sao Paulo Review Tropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associated with increased patients’ morbidity and mortality. In most countries, kidney disease associated to tropical diseases is attended at health services with poor infrastructure and inadequate preventive measures. The long-term impacts of these infections on kidney tissue may be a main cause of future kidney disease in these patients. Therefore, the investigation of novel kidney injury biomarkers in these tropical diseases is of utmost importance to explain the mechanisms of kidney injury, to improve their diagnosis and prognosis, as well as the assessment to health systems by these patients. Since 2011, our group has been studying renal biomarkers in visceral and cutaneous leishmaniasis, schistosomiasis, leptospirosis and leprosy. This study has increased the knowledge on the pathophysiology of kidney disease in the presence of these infections and has contributed to the early diagnosis of kidney injury, pointing to glomerular, endothelial and inflammatory involvement as the main causes of the mechanisms leading to nephropathy and clinical complications. Future perspectives comprise establishing long-term cohort groups to assess the development of kidney disease and the patients’ survival, as well as the use of new biomarkers such as urinary exosomes to detect risk groups and to understand the progression of kidney injuries. Instituto de Medicina Tropical 2020-02-14 /pmc/articles/PMC7032010/ /pubmed/32074217 http://dx.doi.org/10.1590/S1678-9946202062014 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Meneses, Gdayllon Cavalcante da Silva, Geraldo Bezerra Tôrres, Paulo Pacelli Bezerra Filizola de Castro, Valeska Queiroz Lopes, Renata Lima Martins, Alice Maria Costa Daher, Elizabeth De Francesco Novel kidney injury biomarkers in tropical infections: a review of the literature |
title | Novel kidney injury biomarkers in tropical infections: a review of
the literature |
title_full | Novel kidney injury biomarkers in tropical infections: a review of
the literature |
title_fullStr | Novel kidney injury biomarkers in tropical infections: a review of
the literature |
title_full_unstemmed | Novel kidney injury biomarkers in tropical infections: a review of
the literature |
title_short | Novel kidney injury biomarkers in tropical infections: a review of
the literature |
title_sort | novel kidney injury biomarkers in tropical infections: a review of
the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032010/ https://www.ncbi.nlm.nih.gov/pubmed/32074217 http://dx.doi.org/10.1590/S1678-9946202062014 |
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