A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates

Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs. However, potential application of MCT1 to facilitate the oral delivery is...

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Detalles Bibliográficos
Autores principales: Sun, Yixin, Zhao, Dongyang, Wang, Gang, Jiang, Qikun, Guo, Mengran, Kan, Qiming, He, Zhonggui, Sun, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032090/
https://www.ncbi.nlm.nih.gov/pubmed/32104489
http://dx.doi.org/10.1016/j.ajps.2019.04.001

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