Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system

A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chromatography (UPLC-MS) method is developed to investigate its pharmacokinetics and b...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Li, Juan, Li, Zhi, Tang, Xing, Zhang, Zhenzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032114/
https://www.ncbi.nlm.nih.gov/pubmed/32104367
http://dx.doi.org/10.1016/j.ajps.2017.05.005
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author Liu, Yang
Li, Juan
Li, Zhi
Tang, Xing
Zhang, Zhenzhong
author_facet Liu, Yang
Li, Juan
Li, Zhi
Tang, Xing
Zhang, Zhenzhong
author_sort Liu, Yang
collection PubMed
description A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chromatography (UPLC-MS) method is developed to investigate its pharmacokinetics and biodistribution in tumor bearing mice. The results demonstrated that the conjugate circulated for a much longer time in the blood circulation system than commercial 10-HCPT injection, and bioavailability was significantly improved compared with 10-HCPT. In vivo biodistribution study showed that the conjugate could enhance the targeting and residence time in tumor site.
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spelling pubmed-70321142020-02-26 Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system Liu, Yang Li, Juan Li, Zhi Tang, Xing Zhang, Zhenzhong Asian J Pharm Sci Original Research Article A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chromatography (UPLC-MS) method is developed to investigate its pharmacokinetics and biodistribution in tumor bearing mice. The results demonstrated that the conjugate circulated for a much longer time in the blood circulation system than commercial 10-HCPT injection, and bioavailability was significantly improved compared with 10-HCPT. In vivo biodistribution study showed that the conjugate could enhance the targeting and residence time in tumor site. Shenyang Pharmaceutical University 2017-11 2017-05-23 /pmc/articles/PMC7032114/ /pubmed/32104367 http://dx.doi.org/10.1016/j.ajps.2017.05.005 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Liu, Yang
Li, Juan
Li, Zhi
Tang, Xing
Zhang, Zhenzhong
Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
title Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
title_full Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
title_fullStr Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
title_full_unstemmed Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
title_short Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
title_sort pharmacokinetics of a ternary conjugate based ph-responsive 10-hcpt prodrug nano-micelle delivery system
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032114/
https://www.ncbi.nlm.nih.gov/pubmed/32104367
http://dx.doi.org/10.1016/j.ajps.2017.05.005
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