LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG(2000) nanoformulation: What if traditional methods are not applicable?

Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPE-mPEG(2000) can interfere with the limulus amebocyte lysate assay (LAL). Furthermore, the rabb...

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Detalles Bibliográficos
Autores principales: Jin, Yanan, Jia, Juanjuan, Li, Chan, Xue, Jianqi, Sun, Jiabei, Wang, Kaiyuan, Gan, Yaling, Xu, Jing, Shi, Yaqin, Liang, Xingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032139/
https://www.ncbi.nlm.nih.gov/pubmed/32104402
http://dx.doi.org/10.1016/j.ajps.2017.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032139/
https://www.ncbi.nlm.nih.gov/pubmed/32104402
http://dx.doi.org/10.1016/j.ajps.2017.11.003

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