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Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets

Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub- and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how...

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Autores principales: Wang, Xiuzhi, Wang, Puxiu, Huang, Chenglong, Lin, Xiaoyang, Gong, Haoyu, He, Haibing, Cai, Cuifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032155/
https://www.ncbi.nlm.nih.gov/pubmed/32104338
http://dx.doi.org/10.1016/j.ajps.2016.11.003
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author Wang, Xiuzhi
Wang, Puxiu
Huang, Chenglong
Lin, Xiaoyang
Gong, Haoyu
He, Haibing
Cai, Cuifang
author_facet Wang, Xiuzhi
Wang, Puxiu
Huang, Chenglong
Lin, Xiaoyang
Gong, Haoyu
He, Haibing
Cai, Cuifang
author_sort Wang, Xiuzhi
collection PubMed
description Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub- and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate (GMS) as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets (ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability.
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spelling pubmed-70321552020-02-26 Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets Wang, Xiuzhi Wang, Puxiu Huang, Chenglong Lin, Xiaoyang Gong, Haoyu He, Haibing Cai, Cuifang Asian J Pharm Sci Original Research Article Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub- and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate (GMS) as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets (ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability. Shenyang Pharmaceutical University 2017-05 2016-12-21 /pmc/articles/PMC7032155/ /pubmed/32104338 http://dx.doi.org/10.1016/j.ajps.2016.11.003 Text en © 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Wang, Xiuzhi
Wang, Puxiu
Huang, Chenglong
Lin, Xiaoyang
Gong, Haoyu
He, Haibing
Cai, Cuifang
Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
title Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
title_full Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
title_fullStr Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
title_full_unstemmed Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
title_short Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
title_sort hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032155/
https://www.ncbi.nlm.nih.gov/pubmed/32104338
http://dx.doi.org/10.1016/j.ajps.2016.11.003
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