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Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics
A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative (2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated. The conventional plasm...
Autores principales: | Wang, Gang, Zhao, Dongyang, Chen, Hongxiang, Ding, Dawei, Kou, Longfa, Sun, Lifang, Hao, Chenxia, Li, Xincong, Jia, Kai, Kan, Qiming, Liu, Xiaohong, He, Zhonggui, Sun, Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032160/ https://www.ncbi.nlm.nih.gov/pubmed/32104361 http://dx.doi.org/10.1016/j.ajps.2017.01.001 |
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