Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics

A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative (2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated. The conventional plasm...

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Detalles Bibliográficos
Autores principales: Wang, Gang, Zhao, Dongyang, Chen, Hongxiang, Ding, Dawei, Kou, Longfa, Sun, Lifang, Hao, Chenxia, Li, Xincong, Jia, Kai, Kan, Qiming, Liu, Xiaohong, He, Zhonggui, Sun, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032160/
https://www.ncbi.nlm.nih.gov/pubmed/32104361
http://dx.doi.org/10.1016/j.ajps.2017.01.001

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