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Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral...

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Detalles Bibliográficos
Autores principales:	Ohkubo, Atsuko, Chida, Tomomi, Kikuchi, Hidetomo, Tsuda, Tadashi, Sunaga, Katsuyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shenyang Pharmaceutical University 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032185/ https://www.ncbi.nlm.nih.gov/pubmed/32104359 http://dx.doi.org/10.1016/j.ajps.2017.05.004

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