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Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032212/ https://www.ncbi.nlm.nih.gov/pubmed/32104353 http://dx.doi.org/10.1016/j.ajps.2017.05.001 |
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author | Osamura, Takashi Takeuchi, Yoshiko Onodera, Risako Kitamura, Masahiro Takahashi, Yoshiteru Tahara, Kohei Takeuchi, Hirofumi |
author_facet | Osamura, Takashi Takeuchi, Yoshiko Onodera, Risako Kitamura, Masahiro Takahashi, Yoshiteru Tahara, Kohei Takeuchi, Hirofumi |
author_sort | Osamura, Takashi |
collection | PubMed |
description | We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure “Tableting properties” with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad “Manufacturability”, leading to sticking of powder on punches. We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine. |
format | Online Article Text |
id | pubmed-7032212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-70322122020-02-26 Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press Osamura, Takashi Takeuchi, Yoshiko Onodera, Risako Kitamura, Masahiro Takahashi, Yoshiteru Tahara, Kohei Takeuchi, Hirofumi Asian J Pharm Sci Original Research Article We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure “Tableting properties” with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad “Manufacturability”, leading to sticking of powder on punches. We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine. Shenyang Pharmaceutical University 2017-09 2017-05-17 /pmc/articles/PMC7032212/ /pubmed/32104353 http://dx.doi.org/10.1016/j.ajps.2017.05.001 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Osamura, Takashi Takeuchi, Yoshiko Onodera, Risako Kitamura, Masahiro Takahashi, Yoshiteru Tahara, Kohei Takeuchi, Hirofumi Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
title | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
title_full | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
title_fullStr | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
title_full_unstemmed | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
title_short | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
title_sort | prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032212/ https://www.ncbi.nlm.nih.gov/pubmed/32104353 http://dx.doi.org/10.1016/j.ajps.2017.05.001 |
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