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Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur...

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Detalles Bibliográficos
Autores principales: Osamura, Takashi, Takeuchi, Yoshiko, Onodera, Risako, Kitamura, Masahiro, Takahashi, Yoshiteru, Tahara, Kohei, Takeuchi, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032212/
https://www.ncbi.nlm.nih.gov/pubmed/32104353
http://dx.doi.org/10.1016/j.ajps.2017.05.001
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author Osamura, Takashi
Takeuchi, Yoshiko
Onodera, Risako
Kitamura, Masahiro
Takahashi, Yoshiteru
Tahara, Kohei
Takeuchi, Hirofumi
author_facet Osamura, Takashi
Takeuchi, Yoshiko
Onodera, Risako
Kitamura, Masahiro
Takahashi, Yoshiteru
Tahara, Kohei
Takeuchi, Hirofumi
author_sort Osamura, Takashi
collection PubMed
description We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure “Tableting properties” with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad “Manufacturability”, leading to sticking of powder on punches. We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.
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spelling pubmed-70322122020-02-26 Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press Osamura, Takashi Takeuchi, Yoshiko Onodera, Risako Kitamura, Masahiro Takahashi, Yoshiteru Tahara, Kohei Takeuchi, Hirofumi Asian J Pharm Sci Original Research Article We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure “Tableting properties” with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad “Manufacturability”, leading to sticking of powder on punches. We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine. Shenyang Pharmaceutical University 2017-09 2017-05-17 /pmc/articles/PMC7032212/ /pubmed/32104353 http://dx.doi.org/10.1016/j.ajps.2017.05.001 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Osamura, Takashi
Takeuchi, Yoshiko
Onodera, Risako
Kitamura, Masahiro
Takahashi, Yoshiteru
Tahara, Kohei
Takeuchi, Hirofumi
Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
title Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
title_full Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
title_fullStr Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
title_full_unstemmed Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
title_short Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
title_sort prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032212/
https://www.ncbi.nlm.nih.gov/pubmed/32104353
http://dx.doi.org/10.1016/j.ajps.2017.05.001
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