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Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug

In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-c...

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Autores principales: Wang, Xin, Li, Chang, Fan, Na, Li, Jing, Zhang, Haotian, Shang, Lei, He, Zhonggui, Sun, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032221/
https://www.ncbi.nlm.nih.gov/pubmed/32104469
http://dx.doi.org/10.1016/j.ajps.2018.04.002
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author Wang, Xin
Li, Chang
Fan, Na
Li, Jing
Zhang, Haotian
Shang, Lei
He, Zhonggui
Sun, Jin
author_facet Wang, Xin
Li, Chang
Fan, Na
Li, Jing
Zhang, Haotian
Shang, Lei
He, Zhonggui
Sun, Jin
author_sort Wang, Xin
collection PubMed
description In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles (MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium.
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spelling pubmed-70322212020-02-26 Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug Wang, Xin Li, Chang Fan, Na Li, Jing Zhang, Haotian Shang, Lei He, Zhonggui Sun, Jin Asian J Pharm Sci Research Article In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles (MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium. Shenyang Pharmaceutical University 2019-07 2018-07-01 /pmc/articles/PMC7032221/ /pubmed/32104469 http://dx.doi.org/10.1016/j.ajps.2018.04.002 Text en © 2018 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Wang, Xin
Li, Chang
Fan, Na
Li, Jing
Zhang, Haotian
Shang, Lei
He, Zhonggui
Sun, Jin
Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
title Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
title_full Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
title_fullStr Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
title_full_unstemmed Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
title_short Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
title_sort amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032221/
https://www.ncbi.nlm.nih.gov/pubmed/32104469
http://dx.doi.org/10.1016/j.ajps.2018.04.002
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