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Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug
In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032221/ https://www.ncbi.nlm.nih.gov/pubmed/32104469 http://dx.doi.org/10.1016/j.ajps.2018.04.002 |
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author | Wang, Xin Li, Chang Fan, Na Li, Jing Zhang, Haotian Shang, Lei He, Zhonggui Sun, Jin |
author_facet | Wang, Xin Li, Chang Fan, Na Li, Jing Zhang, Haotian Shang, Lei He, Zhonggui Sun, Jin |
author_sort | Wang, Xin |
collection | PubMed |
description | In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles (MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium. |
format | Online Article Text |
id | pubmed-7032221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-70322212020-02-26 Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug Wang, Xin Li, Chang Fan, Na Li, Jing Zhang, Haotian Shang, Lei He, Zhonggui Sun, Jin Asian J Pharm Sci Research Article In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles (MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium. Shenyang Pharmaceutical University 2019-07 2018-07-01 /pmc/articles/PMC7032221/ /pubmed/32104469 http://dx.doi.org/10.1016/j.ajps.2018.04.002 Text en © 2018 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Wang, Xin Li, Chang Fan, Na Li, Jing Zhang, Haotian Shang, Lei He, Zhonggui Sun, Jin Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
title | Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
title_full | Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
title_fullStr | Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
title_full_unstemmed | Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
title_short | Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
title_sort | amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032221/ https://www.ncbi.nlm.nih.gov/pubmed/32104469 http://dx.doi.org/10.1016/j.ajps.2018.04.002 |
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