Cargando…
Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline
An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM). The spray drying technique was sele...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032243/ https://www.ncbi.nlm.nih.gov/pubmed/32104371 http://dx.doi.org/10.1016/j.ajps.2017.07.009 |
_version_ | 1783499535611330560 |
---|---|
author | Wei, Shijie Ren, Jingbo Li, Ning Huo, Wuzhen Gao, Chongkai |
author_facet | Wei, Shijie Ren, Jingbo Li, Ning Huo, Wuzhen Gao, Chongkai |
author_sort | Wei, Shijie |
collection | PubMed |
description | An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM). The spray drying technique was selected to dry and solidify particles into powder. The in vitro release of Fen-LCC was measured and in vivo pharmacokinetic experiments were carried out on rats after oral administration. Particles prepared through the high-temperature input method exhibited structural characteristics of LCC, and re-dissolved particles maintained the same features. The LCC delivery system can significantly improve in vitro release outcomes. After oral administration, AUCs of the suspension and LCC systems were measured at 131.6853 µg⋅h/ml and 1435.72893 µg⋅h/ml, respectively. The spray drying process presented here better maintains cubic structures, and the LCC system significantly improves bioavailability levels. |
format | Online Article Text |
id | pubmed-7032243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-70322432020-02-26 Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline Wei, Shijie Ren, Jingbo Li, Ning Huo, Wuzhen Gao, Chongkai Asian J Pharm Sci Original Research Article An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM). The spray drying technique was selected to dry and solidify particles into powder. The in vitro release of Fen-LCC was measured and in vivo pharmacokinetic experiments were carried out on rats after oral administration. Particles prepared through the high-temperature input method exhibited structural characteristics of LCC, and re-dissolved particles maintained the same features. The LCC delivery system can significantly improve in vitro release outcomes. After oral administration, AUCs of the suspension and LCC systems were measured at 131.6853 µg⋅h/ml and 1435.72893 µg⋅h/ml, respectively. The spray drying process presented here better maintains cubic structures, and the LCC system significantly improves bioavailability levels. Shenyang Pharmaceutical University 2017-11 2017-08-02 /pmc/articles/PMC7032243/ /pubmed/32104371 http://dx.doi.org/10.1016/j.ajps.2017.07.009 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Wei, Shijie Ren, Jingbo Li, Ning Huo, Wuzhen Gao, Chongkai Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
title | Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
title_full | Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
title_fullStr | Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
title_full_unstemmed | Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
title_short | Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
title_sort | preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032243/ https://www.ncbi.nlm.nih.gov/pubmed/32104371 http://dx.doi.org/10.1016/j.ajps.2017.07.009 |
work_keys_str_mv | AT weishijie preparationandpharmacokineticstudyoffenofibratecubicliquidcrystalline AT renjingbo preparationandpharmacokineticstudyoffenofibratecubicliquidcrystalline AT lining preparationandpharmacokineticstudyoffenofibratecubicliquidcrystalline AT huowuzhen preparationandpharmacokineticstudyoffenofibratecubicliquidcrystalline AT gaochongkai preparationandpharmacokineticstudyoffenofibratecubicliquidcrystalline |