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Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid (OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion (HME) was applied to develop OA amorphous solid dispersions. The characterizations of the optimal formulation were...

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Detalles Bibliográficos
Autores principales:	Gao, Nannan, Guo, Mengran, Fu, Qiang, He, Zhonggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shenyang Pharmaceutical University 2017
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032251/ https://www.ncbi.nlm.nih.gov/pubmed/32104315 http://dx.doi.org/10.1016/j.ajps.2016.06.006

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