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Multi-state design of flexible proteins predicts sequences optimal for conformational change
Computational protein design of an ensemble of conformations for one protein–i.e., multi-state design–determines the side chain identity by optimizing the energetic contributions of that side chain in each of the backbone conformations. Sampling the resulting large sequence-structure search space li...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032724/ https://www.ncbi.nlm.nih.gov/pubmed/32032348 http://dx.doi.org/10.1371/journal.pcbi.1007339 |