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Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cells. Overexpression and mislocalization of CENP-A ha...

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Detalles Bibliográficos
Autores principales:	Au, Wei-Chun, Zhang, Tianyi, Mishra, Prashant K., Eisenstatt, Jessica R., Walker, Robert L., Ocampo, Josefina, Dawson, Anthony, Warren, Jack, Costanzo, Michael, Baryshnikova, Anastasia, Flick, Karin, Clark, David J., Meltzer, Paul S., Baker, Richard E., Myers, Chad, Boone, Charles, Kaiser, Peter, Basrai, Munira A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032732/ https://www.ncbi.nlm.nih.gov/pubmed/32032354 http://dx.doi.org/10.1371/journal.pgen.1008597

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