Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

Arc, a neuronal gene critical for synaptic plasticity, originated through domestication of retrotransposon Gag genes and mediates intercellular mRNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative in...

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Autores principales: Erlendsson, Simon, Morado, Dustin R., Cullen, Harrison B., Feschotte, Cedric, Shepherd, Jason D., Briggs, John A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032958/
https://www.ncbi.nlm.nih.gov/pubmed/31907439
http://dx.doi.org/10.1038/s41593-019-0569-y
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author Erlendsson, Simon
Morado, Dustin R.
Cullen, Harrison B.
Feschotte, Cedric
Shepherd, Jason D.
Briggs, John A. G.
author_facet Erlendsson, Simon
Morado, Dustin R.
Cullen, Harrison B.
Feschotte, Cedric
Shepherd, Jason D.
Briggs, John A. G.
author_sort Erlendsson, Simon
collection PubMed
description Arc, a neuronal gene critical for synaptic plasticity, originated through domestication of retrotransposon Gag genes and mediates intercellular mRNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
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spelling pubmed-70329582020-07-06 Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins Erlendsson, Simon Morado, Dustin R. Cullen, Harrison B. Feschotte, Cedric Shepherd, Jason D. Briggs, John A. G. Nat Neurosci Article Arc, a neuronal gene critical for synaptic plasticity, originated through domestication of retrotransposon Gag genes and mediates intercellular mRNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication. 2020-01-06 2020-02 /pmc/articles/PMC7032958/ /pubmed/31907439 http://dx.doi.org/10.1038/s41593-019-0569-y Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Erlendsson, Simon
Morado, Dustin R.
Cullen, Harrison B.
Feschotte, Cedric
Shepherd, Jason D.
Briggs, John A. G.
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
title Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
title_full Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
title_fullStr Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
title_full_unstemmed Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
title_short Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
title_sort structures of virus-like capsids formed by the drosophila neuronal arc proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032958/
https://www.ncbi.nlm.nih.gov/pubmed/31907439
http://dx.doi.org/10.1038/s41593-019-0569-y
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