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The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology
While hormonal changes during the ovulatory cycles affect multiple body systems, medical management, including medication dosing remains largely uniform between the sexes. Little is known about sex-specific pharmacology in women. Although hormonal fluctuations of the normal menstruating process alte...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Clinical Pharmacology and Therapeutics
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032965/ https://www.ncbi.nlm.nih.gov/pubmed/32095480 http://dx.doi.org/10.12793/tcp.2019.27.4.127 |
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author | Yum, Sun Kyoung Yum, Sun Young Kim, Tak |
author_facet | Yum, Sun Kyoung Yum, Sun Young Kim, Tak |
author_sort | Yum, Sun Kyoung |
collection | PubMed |
description | While hormonal changes during the ovulatory cycles affect multiple body systems, medical management, including medication dosing remains largely uniform between the sexes. Little is known about sex-specific pharmacology in women. Although hormonal fluctuations of the normal menstruating process alters women's physiology and brain biochemistry, medication dosing does not consider such cyclical changes. Using schizophrenia as an example, this paper illustrates how a woman's clinical symptoms can change throughout the ovulatory cycle, leading to fluctuations in medication responses. Effects of sex steroids on the brain, clinical pharmacology are discussed. Effective medication dose may be different at different phases of the menstrual cycle. Further research is needed to better understand optimal treatment strategies in reproductive women; we present a potential clinical trial design for examining optimal medication dosing strategies for conditions that have menstruation related clinical fluctuations. |
format | Online Article Text |
id | pubmed-7032965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society for Clinical Pharmacology and Therapeutics |
record_format | MEDLINE/PubMed |
spelling | pubmed-70329652020-02-24 The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology Yum, Sun Kyoung Yum, Sun Young Kim, Tak Transl Clin Pharmacol Review While hormonal changes during the ovulatory cycles affect multiple body systems, medical management, including medication dosing remains largely uniform between the sexes. Little is known about sex-specific pharmacology in women. Although hormonal fluctuations of the normal menstruating process alters women's physiology and brain biochemistry, medication dosing does not consider such cyclical changes. Using schizophrenia as an example, this paper illustrates how a woman's clinical symptoms can change throughout the ovulatory cycle, leading to fluctuations in medication responses. Effects of sex steroids on the brain, clinical pharmacology are discussed. Effective medication dose may be different at different phases of the menstrual cycle. Further research is needed to better understand optimal treatment strategies in reproductive women; we present a potential clinical trial design for examining optimal medication dosing strategies for conditions that have menstruation related clinical fluctuations. Korean Society for Clinical Pharmacology and Therapeutics 2019-12 2019-12-31 /pmc/articles/PMC7032965/ /pubmed/32095480 http://dx.doi.org/10.12793/tcp.2019.27.4.127 Text en Copyright © 2019 Tak Kim http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/). |
spellingShingle | Review Yum, Sun Kyoung Yum, Sun Young Kim, Tak The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
title | The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
title_full | The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
title_fullStr | The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
title_full_unstemmed | The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
title_short | The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
title_sort | problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032965/ https://www.ncbi.nlm.nih.gov/pubmed/32095480 http://dx.doi.org/10.12793/tcp.2019.27.4.127 |
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