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Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research

In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations that then lead back to the bedside. This article chronicles the evolution of a...

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Autor principal: Atkinson, Arthur J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032968/
https://www.ncbi.nlm.nih.gov/pubmed/32095478
http://dx.doi.org/10.12793/tcp.2019.27.4.119
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author Atkinson, Arthur J.
author_facet Atkinson, Arthur J.
author_sort Atkinson, Arthur J.
collection PubMed
description In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations that then lead back to the bedside. This article chronicles the evolution of a series of studies in which a detailed analysis of pharmacokinetics in hemodialysis patients revealed new physiological insight that, through a systems approach incorporating kinetic, physicochemical, physiologic, and clinical trial results, led to an elucidation of the pathophysiology of intradialytic skeletal muscle cramps. Based on this understanding, a therapeutic path forward is proposed.
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spelling pubmed-70329682020-02-24 Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research Atkinson, Arthur J. Transl Clin Pharmacol Tutorial In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations that then lead back to the bedside. This article chronicles the evolution of a series of studies in which a detailed analysis of pharmacokinetics in hemodialysis patients revealed new physiological insight that, through a systems approach incorporating kinetic, physicochemical, physiologic, and clinical trial results, led to an elucidation of the pathophysiology of intradialytic skeletal muscle cramps. Based on this understanding, a therapeutic path forward is proposed. Korean Society for Clinical Pharmacology and Therapeutics 2019-12 2019-12-31 /pmc/articles/PMC7032968/ /pubmed/32095478 http://dx.doi.org/10.12793/tcp.2019.27.4.119 Text en Copyright © 2019 Arthur J. Atkinson, Jr. http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).
spellingShingle Tutorial
Atkinson, Arthur J.
Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
title Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
title_full Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
title_fullStr Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
title_full_unstemmed Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
title_short Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
title_sort elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032968/
https://www.ncbi.nlm.nih.gov/pubmed/32095478
http://dx.doi.org/10.12793/tcp.2019.27.4.119
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