MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and provides few common therapeutic targets. We found that MCL1, Cofilin1 (CFL1) and SRC mRNA were highly expressed by a wide range of these cancers, su...

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Detalles Bibliográficos
Autores principales: Castillo, Lesley, Young, Adelaide I. J., Mawson, Amanda, Schafranek, Pia, Steinmann, Angela M., Nessem, Danielle, Parkin, Ashleigh, Johns, Amber, Chou, Angela, Law, Andrew M. K., Lucas, Morghan C., Murphy, Kendelle J., Deng, Niantao, Gallego-Ortega, David, Caldon, Catherine E., Timpson, Paul, Pajic, Marina, Ormandy, Christopher J., Oakes, Samantha R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033042/
https://www.ncbi.nlm.nih.gov/pubmed/31735913
http://dx.doi.org/10.1038/s41388-019-1091-0

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