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The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults

OBJECTIVES: Assessment of the repeatability of diffusion parameter estimations in the upper leg muscles of healthy adults over the time course of 2 weeks, from a simultaneous bilateral upper leg DTI measurement. METHODS: SE-EPI DTI datasets were acquired at 3 T in the upper legs of 15 active adults...

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Autores principales: Monte, Jithsa R., Hooijmans, Melissa T., Froeling, Martijn, Oudeman, Jos, Tol, Johannes L., Maas, Mario, Strijkers, Gustav J., Nederveen, Aart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033061/
https://www.ncbi.nlm.nih.gov/pubmed/31705253
http://dx.doi.org/10.1007/s00330-019-06403-5
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author Monte, Jithsa R.
Hooijmans, Melissa T.
Froeling, Martijn
Oudeman, Jos
Tol, Johannes L.
Maas, Mario
Strijkers, Gustav J.
Nederveen, Aart J.
author_facet Monte, Jithsa R.
Hooijmans, Melissa T.
Froeling, Martijn
Oudeman, Jos
Tol, Johannes L.
Maas, Mario
Strijkers, Gustav J.
Nederveen, Aart J.
author_sort Monte, Jithsa R.
collection PubMed
description OBJECTIVES: Assessment of the repeatability of diffusion parameter estimations in the upper leg muscles of healthy adults over the time course of 2 weeks, from a simultaneous bilateral upper leg DTI measurement. METHODS: SE-EPI DTI datasets were acquired at 3 T in the upper legs of 15 active adults at a time interval of 2 weeks. ROIs were manually drawn for four quadriceps and three hamstring muscles of both legs. The following DTI parameters were analyzed: 1st, 2nd, and 3rd eigenvalue (λ(1), λ(2), and λ(3)), mean diffusivity (MD), and fractional anisotropy (FA). DTI parameters per muscle were calculated with and without intravoxel incoherent motion (IVIM) correction together with SNR levels per muscle. Bland-Altman plots and within-subject coefficient of variation (wsCV) were calculated. Left-right differences between muscles were assessed. RESULTS: The Bland-Altman analysis showed good repeatability of all DTI parameters except FA for both the IVIM-corrected and standard data. wsCV values show that MD has the highest repeatability (4.5% IVIM; 5.6% standard), followed by λ(2) (4.9% IVIM; 5.5% standard), λ(1) (5.3% IVIM; 7.5% standard), and λ(3) (5.7% IVIM; 5.7% standard). wsCV values of FA were 15.2% for the IVIM-corrected data and 13.9% for the standard analysis. The SNR (41.8 ± 16.0 right leg, 41.7 ± 17.1 left leg) and wsCV values were similar for the left and right leg and no left-right bias was detected. CONCLUSIONS: Repeatability was good for standard DTI data and slightly better for IVIM-corrected DTI data. Our protocol is suitable for DTI of the upper legs with overall good SNR. KEY POINTS: • The presented DTI protocol is repeatable and therefore suitable for bilateral DT imaging of the upper legs. • Additional B1 (+) calibrations improve SNR and repeatability. • Correcting for perfusion effects improves repeatability. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-019-06403-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-70330612020-03-06 The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults Monte, Jithsa R. Hooijmans, Melissa T. Froeling, Martijn Oudeman, Jos Tol, Johannes L. Maas, Mario Strijkers, Gustav J. Nederveen, Aart J. Eur Radiol Magnetic Resonance OBJECTIVES: Assessment of the repeatability of diffusion parameter estimations in the upper leg muscles of healthy adults over the time course of 2 weeks, from a simultaneous bilateral upper leg DTI measurement. METHODS: SE-EPI DTI datasets were acquired at 3 T in the upper legs of 15 active adults at a time interval of 2 weeks. ROIs were manually drawn for four quadriceps and three hamstring muscles of both legs. The following DTI parameters were analyzed: 1st, 2nd, and 3rd eigenvalue (λ(1), λ(2), and λ(3)), mean diffusivity (MD), and fractional anisotropy (FA). DTI parameters per muscle were calculated with and without intravoxel incoherent motion (IVIM) correction together with SNR levels per muscle. Bland-Altman plots and within-subject coefficient of variation (wsCV) were calculated. Left-right differences between muscles were assessed. RESULTS: The Bland-Altman analysis showed good repeatability of all DTI parameters except FA for both the IVIM-corrected and standard data. wsCV values show that MD has the highest repeatability (4.5% IVIM; 5.6% standard), followed by λ(2) (4.9% IVIM; 5.5% standard), λ(1) (5.3% IVIM; 7.5% standard), and λ(3) (5.7% IVIM; 5.7% standard). wsCV values of FA were 15.2% for the IVIM-corrected data and 13.9% for the standard analysis. The SNR (41.8 ± 16.0 right leg, 41.7 ± 17.1 left leg) and wsCV values were similar for the left and right leg and no left-right bias was detected. CONCLUSIONS: Repeatability was good for standard DTI data and slightly better for IVIM-corrected DTI data. Our protocol is suitable for DTI of the upper legs with overall good SNR. KEY POINTS: • The presented DTI protocol is repeatable and therefore suitable for bilateral DT imaging of the upper legs. • Additional B1 (+) calibrations improve SNR and repeatability. • Correcting for perfusion effects improves repeatability. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-019-06403-5) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-11-08 2020 /pmc/articles/PMC7033061/ /pubmed/31705253 http://dx.doi.org/10.1007/s00330-019-06403-5 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Magnetic Resonance
Monte, Jithsa R.
Hooijmans, Melissa T.
Froeling, Martijn
Oudeman, Jos
Tol, Johannes L.
Maas, Mario
Strijkers, Gustav J.
Nederveen, Aart J.
The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults
title The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults
title_full The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults
title_fullStr The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults
title_full_unstemmed The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults
title_short The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults
title_sort repeatability of bilateral diffusion tensor imaging (dti) in the upper leg muscles of healthy adults
topic Magnetic Resonance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033061/
https://www.ncbi.nlm.nih.gov/pubmed/31705253
http://dx.doi.org/10.1007/s00330-019-06403-5
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