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Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling

OBJECTIVE: Boron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[(18)F]-fluoro-L-phenylalanine ((18)F-FBPA) PET has been employed to estimate (10)B accumulation in target tumors and normal tissues if (10)B borono-L-phenylalanine ((1...

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Autores principales: Romanov, Victor, Isohashi, Kayako, Alobthani, Galal, Beshr, Rouaa, Horitsugi, Genki, Kanai, Yasukazu, Naka, Sadahiro, Watabe, Tadashi, Shimosegawa, Eku, Hatazawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033086/
https://www.ncbi.nlm.nih.gov/pubmed/31808134
http://dx.doi.org/10.1007/s12149-019-01427-9
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author Romanov, Victor
Isohashi, Kayako
Alobthani, Galal
Beshr, Rouaa
Horitsugi, Genki
Kanai, Yasukazu
Naka, Sadahiro
Watabe, Tadashi
Shimosegawa, Eku
Hatazawa, Jun
author_facet Romanov, Victor
Isohashi, Kayako
Alobthani, Galal
Beshr, Rouaa
Horitsugi, Genki
Kanai, Yasukazu
Naka, Sadahiro
Watabe, Tadashi
Shimosegawa, Eku
Hatazawa, Jun
author_sort Romanov, Victor
collection PubMed
description OBJECTIVE: Boron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[(18)F]-fluoro-L-phenylalanine ((18)F-FBPA) PET has been employed to estimate (10)B accumulation in target tumors and normal tissues if (10)B borono-L-phenylalanine ((10)B-BPA) is used as a boron carrier. The purpose of the current study was to evaluate the total distribution volume (Vt) of (18)F-FBPA in normal organs of healthy volunteers by kinetic analysis and to estimate boron concentration in normal organs for the therapeutic dose of (10)B-BPA using obtained Vt values. METHODS: Six healthy volunteers were injected with (18)F-FBPA (3–5 MBq/kg), and 7 PET-CT scans were performed subsequently. (18)F-FBPA radioactivity in whole blood and plasma was measured before, and eight times after the injection. PET images were analyzed by PMOD software. Twelve volumetric regions of interest including the brain, heart, right lung, spleen, liver, parotid salivary glands, esophagus, stomach, pancreas, intestines, and bone marrow were drawn manually for each subject and analyzed with the Logan plot and two Ichise multilinear analyses (MA1 and MA2). The better model was defined by several goodness-of-fit parameters and residual distribution. After Vt values had been derived, boron concentration was estimated in ppm for the (10)B-BPA-fructose ((10)B-BPA-fr) dose 30 g 1 and 2 h post-injection using Vt and interpolated plasma activity data. RESULTS: The Ichise MA2 model showed the best fit among all models. Akaike Information Criterion (AIC) was the lowest for the Ichise’s MA2 in all regions (mean AIC value − 14.0) comparing to the other models (Logan plot mean AIC 31.4; Ichise MA1 model mean AIC − 4.2). Mean Vt values of the Ichise MA2 model ranged from 0.94 ± 0.14 ml/ml in the pancreas to 0.16 ± 0.02 ml/ml in the right lung. Estimated boron concentration for (10)B-BPA-fr had the highest value in the pancreas (14.0 ± 1.9 ppm 1 h after, and 5.7 ± 1.7 ppm 2 h after the (18)F-FBPA administration) and the lowest value in the right lung (2.4 ± 0.3 ppm 1 h, and 1.0 ± 0.3 ppm 2 h post-injection). CONCLUSION: The (10)B concentration in normal tissues was best estimated using Vt values of (18)F-FBPA with the Ichise multilinear analysis 2 (MA2). TRAIL REGISTRY: The UMIN clinical trial number: UMIN000022850. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12149-019-01427-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-70330862020-03-06 Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling Romanov, Victor Isohashi, Kayako Alobthani, Galal Beshr, Rouaa Horitsugi, Genki Kanai, Yasukazu Naka, Sadahiro Watabe, Tadashi Shimosegawa, Eku Hatazawa, Jun Ann Nucl Med Original Article OBJECTIVE: Boron neutron capture therapy (BNCT) is a noninvasive radiation therapy method for cancer treatment. In BNCT, 4-borono-2-[(18)F]-fluoro-L-phenylalanine ((18)F-FBPA) PET has been employed to estimate (10)B accumulation in target tumors and normal tissues if (10)B borono-L-phenylalanine ((10)B-BPA) is used as a boron carrier. The purpose of the current study was to evaluate the total distribution volume (Vt) of (18)F-FBPA in normal organs of healthy volunteers by kinetic analysis and to estimate boron concentration in normal organs for the therapeutic dose of (10)B-BPA using obtained Vt values. METHODS: Six healthy volunteers were injected with (18)F-FBPA (3–5 MBq/kg), and 7 PET-CT scans were performed subsequently. (18)F-FBPA radioactivity in whole blood and plasma was measured before, and eight times after the injection. PET images were analyzed by PMOD software. Twelve volumetric regions of interest including the brain, heart, right lung, spleen, liver, parotid salivary glands, esophagus, stomach, pancreas, intestines, and bone marrow were drawn manually for each subject and analyzed with the Logan plot and two Ichise multilinear analyses (MA1 and MA2). The better model was defined by several goodness-of-fit parameters and residual distribution. After Vt values had been derived, boron concentration was estimated in ppm for the (10)B-BPA-fructose ((10)B-BPA-fr) dose 30 g 1 and 2 h post-injection using Vt and interpolated plasma activity data. RESULTS: The Ichise MA2 model showed the best fit among all models. Akaike Information Criterion (AIC) was the lowest for the Ichise’s MA2 in all regions (mean AIC value − 14.0) comparing to the other models (Logan plot mean AIC 31.4; Ichise MA1 model mean AIC − 4.2). Mean Vt values of the Ichise MA2 model ranged from 0.94 ± 0.14 ml/ml in the pancreas to 0.16 ± 0.02 ml/ml in the right lung. Estimated boron concentration for (10)B-BPA-fr had the highest value in the pancreas (14.0 ± 1.9 ppm 1 h after, and 5.7 ± 1.7 ppm 2 h after the (18)F-FBPA administration) and the lowest value in the right lung (2.4 ± 0.3 ppm 1 h, and 1.0 ± 0.3 ppm 2 h post-injection). CONCLUSION: The (10)B concentration in normal tissues was best estimated using Vt values of (18)F-FBPA with the Ichise multilinear analysis 2 (MA2). TRAIL REGISTRY: The UMIN clinical trial number: UMIN000022850. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12149-019-01427-9) contains supplementary material, which is available to authorized users. Springer Singapore 2019-12-05 2020 /pmc/articles/PMC7033086/ /pubmed/31808134 http://dx.doi.org/10.1007/s12149-019-01427-9 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Romanov, Victor
Isohashi, Kayako
Alobthani, Galal
Beshr, Rouaa
Horitsugi, Genki
Kanai, Yasukazu
Naka, Sadahiro
Watabe, Tadashi
Shimosegawa, Eku
Hatazawa, Jun
Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling
title Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling
title_full Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling
title_fullStr Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling
title_full_unstemmed Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling
title_short Evaluation of the total distribution volume of (18)F-FBPA in normal tissues of healthy volunteers by non-compartmental kinetic modeling
title_sort evaluation of the total distribution volume of (18)f-fbpa in normal tissues of healthy volunteers by non-compartmental kinetic modeling
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033086/
https://www.ncbi.nlm.nih.gov/pubmed/31808134
http://dx.doi.org/10.1007/s12149-019-01427-9
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