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Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin

Systematic understanding of the metabolite signature of diseases may lead to a closer understanding of the disease pathogenesis and ultimately to the development of novel therapies and diagnostic tools. Here we compared for the first time the full metabolomic profiles of lesional and non-lesional sk...

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Autores principales: Pohla, Liis, Ottas, Aigar, Kaldvee, Bret, Abram, Kristi, Soomets, Ursel, Zilmer, Mihkel, Reemann, Paula, Jaks, Viljar, Kingo, Külli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033101/
https://www.ncbi.nlm.nih.gov/pubmed/32080291
http://dx.doi.org/10.1038/s41598-020-59996-z
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author Pohla, Liis
Ottas, Aigar
Kaldvee, Bret
Abram, Kristi
Soomets, Ursel
Zilmer, Mihkel
Reemann, Paula
Jaks, Viljar
Kingo, Külli
author_facet Pohla, Liis
Ottas, Aigar
Kaldvee, Bret
Abram, Kristi
Soomets, Ursel
Zilmer, Mihkel
Reemann, Paula
Jaks, Viljar
Kingo, Külli
author_sort Pohla, Liis
collection PubMed
description Systematic understanding of the metabolite signature of diseases may lead to a closer understanding of the disease pathogenesis and ultimately to the development of novel therapies and diagnostic tools. Here we compared for the first time the full metabolomic profiles of lesional and non-lesional skin biopsies obtained from plaque psoriasis patients and skin samples of healthy controls. Significant differences in the concentration levels of 29 metabolites were identified that provide several novel insights into the metabolic pathways of psoriatic lesions. The metabolomic profile of the lesional psoriatic skin is mainly characterized by hallmarks of increased cell proliferation. As no significant differences were identified between non-lesional skin and healthy controls we conclude that local inflammatory process that drives the increased cell proliferation is the main cause of the identified metabolomic shifts.
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spelling pubmed-70331012020-02-27 Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin Pohla, Liis Ottas, Aigar Kaldvee, Bret Abram, Kristi Soomets, Ursel Zilmer, Mihkel Reemann, Paula Jaks, Viljar Kingo, Külli Sci Rep Article Systematic understanding of the metabolite signature of diseases may lead to a closer understanding of the disease pathogenesis and ultimately to the development of novel therapies and diagnostic tools. Here we compared for the first time the full metabolomic profiles of lesional and non-lesional skin biopsies obtained from plaque psoriasis patients and skin samples of healthy controls. Significant differences in the concentration levels of 29 metabolites were identified that provide several novel insights into the metabolic pathways of psoriatic lesions. The metabolomic profile of the lesional psoriatic skin is mainly characterized by hallmarks of increased cell proliferation. As no significant differences were identified between non-lesional skin and healthy controls we conclude that local inflammatory process that drives the increased cell proliferation is the main cause of the identified metabolomic shifts. Nature Publishing Group UK 2020-02-20 /pmc/articles/PMC7033101/ /pubmed/32080291 http://dx.doi.org/10.1038/s41598-020-59996-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pohla, Liis
Ottas, Aigar
Kaldvee, Bret
Abram, Kristi
Soomets, Ursel
Zilmer, Mihkel
Reemann, Paula
Jaks, Viljar
Kingo, Külli
Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
title Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
title_full Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
title_fullStr Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
title_full_unstemmed Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
title_short Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
title_sort hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033101/
https://www.ncbi.nlm.nih.gov/pubmed/32080291
http://dx.doi.org/10.1038/s41598-020-59996-z
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