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Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications

Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among children, adolescents, and young adults, who tend to be more caffeine-sen...

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Autores principales: Han, Sungpil, Cho, Yong-Soon, Yoon, Seok-Kyu, Kim, Hyungsub, Bae, Kyun-Seop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033381/
https://www.ncbi.nlm.nih.gov/pubmed/32095465
http://dx.doi.org/10.12793/tcp.2017.25.3.141
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author Han, Sungpil
Cho, Yong-Soon
Yoon, Seok-Kyu
Kim, Hyungsub
Bae, Kyun-Seop
author_facet Han, Sungpil
Cho, Yong-Soon
Yoon, Seok-Kyu
Kim, Hyungsub
Bae, Kyun-Seop
author_sort Han, Sungpil
collection PubMed
description Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among children, adolescents, and young adults, who tend to be more caffeine-sensitive than the rest of the general public; consequently, caffeine-related toxicities among these groups are also growing in number. However, a quantitative and interactive tool for predicting the plasma caffeine concentration that may lead to caffeine intoxication has yet to be developed. Using the previously established population-pharmacokinetic model, we developed “caffsim” R package and its web-based applications using Shiny and EDISON (EDucation-research Integration through Simulation On the Net). The primary aim of the software is to easily predict and calculate plasma caffeine concentration and pharmacokinetic parameters and visualize their changes after single or multiple ingestions of caffeine. The caffsim R package helps understand how plasma caffeine concentration changes over time and how long toxic concentration of caffeine can last in caffeine-sensitive groups. It may also help clinical evaluation of relationship between caffeine intake and toxicities when suspicious acute symptoms occur.
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spelling pubmed-70333812020-02-24 Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications Han, Sungpil Cho, Yong-Soon Yoon, Seok-Kyu Kim, Hyungsub Bae, Kyun-Seop Transl Clin Pharmacol Original Article Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among children, adolescents, and young adults, who tend to be more caffeine-sensitive than the rest of the general public; consequently, caffeine-related toxicities among these groups are also growing in number. However, a quantitative and interactive tool for predicting the plasma caffeine concentration that may lead to caffeine intoxication has yet to be developed. Using the previously established population-pharmacokinetic model, we developed “caffsim” R package and its web-based applications using Shiny and EDISON (EDucation-research Integration through Simulation On the Net). The primary aim of the software is to easily predict and calculate plasma caffeine concentration and pharmacokinetic parameters and visualize their changes after single or multiple ingestions of caffeine. The caffsim R package helps understand how plasma caffeine concentration changes over time and how long toxic concentration of caffeine can last in caffeine-sensitive groups. It may also help clinical evaluation of relationship between caffeine intake and toxicities when suspicious acute symptoms occur. Korean Society for Clinical Pharmacology and Therapeutics 2017-09 2017-09-15 /pmc/articles/PMC7033381/ /pubmed/32095465 http://dx.doi.org/10.12793/tcp.2017.25.3.141 Text en Copyright © 2017 Translational and Clinical Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).
spellingShingle Original Article
Han, Sungpil
Cho, Yong-Soon
Yoon, Seok-Kyu
Kim, Hyungsub
Bae, Kyun-Seop
Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
title Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
title_full Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
title_fullStr Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
title_full_unstemmed Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
title_short Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
title_sort caffsim: simulation of plasma caffeine concentrations implemented as an r package and web-applications
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033381/
https://www.ncbi.nlm.nih.gov/pubmed/32095465
http://dx.doi.org/10.12793/tcp.2017.25.3.141
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