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Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target

Asthma is a chronic and heterogenic disease of the respiratory system, one of the most common lung diseases worldwide. The underlying pathologies, which are chronic inflammatory process and airway remodeling (AR), are mediated by numerous cells and cytokines. Particularly interesting in this field i...

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Autores principales: Kardas, Grzegorz, Daszyńska-Kardas, Agnieszka, Marynowski, Mateusz, Brząkalska, Oliwia, Kuna, Piotr, Panek, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033439/
https://www.ncbi.nlm.nih.gov/pubmed/32116722
http://dx.doi.org/10.3389/fphar.2020.00047
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author Kardas, Grzegorz
Daszyńska-Kardas, Agnieszka
Marynowski, Mateusz
Brząkalska, Oliwia
Kuna, Piotr
Panek, Michał
author_facet Kardas, Grzegorz
Daszyńska-Kardas, Agnieszka
Marynowski, Mateusz
Brząkalska, Oliwia
Kuna, Piotr
Panek, Michał
author_sort Kardas, Grzegorz
collection PubMed
description Asthma is a chronic and heterogenic disease of the respiratory system, one of the most common lung diseases worldwide. The underlying pathologies, which are chronic inflammatory process and airway remodeling (AR), are mediated by numerous cells and cytokines. Particularly interesting in this field is the platelet-derived growth factor (PDGF), one of the members of the human growth factor family. In this article, the authors analyze the available data on the role of PDGF in asthma in experimental models and in human research. PDGF is expressed in airway by various cells contributing to asthma pathogenesis—mast cells, eosinophils, and airway epithelial cells. Research confirms the thesis that this factor is also secreted by these cells in the course of asthma. The main effects of PDGF on bronchi are the proliferation of airway smooth muscle (ASM) cells, migration of ASM cells into the epithelium and enhanced collagen synthesis by lung fibroblasts. The importance of AR in asthma is well recognized and new therapies should also aim to manage it, possibly targeting PDGFRs. Further studies on new and already existing drugs, mediating the PDGF signaling and related to asthma are necessary. Several promising drugs from the tyrosine kinase inhibitors group, including nilotinib, imatinib masitinib, and sunitinib, are currently being clinically tested and other molecules are likely to emerge in this field.
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spelling pubmed-70334392020-02-28 Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target Kardas, Grzegorz Daszyńska-Kardas, Agnieszka Marynowski, Mateusz Brząkalska, Oliwia Kuna, Piotr Panek, Michał Front Pharmacol Pharmacology Asthma is a chronic and heterogenic disease of the respiratory system, one of the most common lung diseases worldwide. The underlying pathologies, which are chronic inflammatory process and airway remodeling (AR), are mediated by numerous cells and cytokines. Particularly interesting in this field is the platelet-derived growth factor (PDGF), one of the members of the human growth factor family. In this article, the authors analyze the available data on the role of PDGF in asthma in experimental models and in human research. PDGF is expressed in airway by various cells contributing to asthma pathogenesis—mast cells, eosinophils, and airway epithelial cells. Research confirms the thesis that this factor is also secreted by these cells in the course of asthma. The main effects of PDGF on bronchi are the proliferation of airway smooth muscle (ASM) cells, migration of ASM cells into the epithelium and enhanced collagen synthesis by lung fibroblasts. The importance of AR in asthma is well recognized and new therapies should also aim to manage it, possibly targeting PDGFRs. Further studies on new and already existing drugs, mediating the PDGF signaling and related to asthma are necessary. Several promising drugs from the tyrosine kinase inhibitors group, including nilotinib, imatinib masitinib, and sunitinib, are currently being clinically tested and other molecules are likely to emerge in this field. Frontiers Media S.A. 2020-02-14 /pmc/articles/PMC7033439/ /pubmed/32116722 http://dx.doi.org/10.3389/fphar.2020.00047 Text en Copyright © 2020 Kardas, Daszyńska-Kardas, Marynowski, Brząkalska, Kuna and Panek http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kardas, Grzegorz
Daszyńska-Kardas, Agnieszka
Marynowski, Mateusz
Brząkalska, Oliwia
Kuna, Piotr
Panek, Michał
Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
title Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
title_full Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
title_fullStr Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
title_full_unstemmed Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
title_short Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
title_sort role of platelet-derived growth factor (pdgf) in asthma as an immunoregulatory factor mediating airway remodeling and possible pharmacological target
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033439/
https://www.ncbi.nlm.nih.gov/pubmed/32116722
http://dx.doi.org/10.3389/fphar.2020.00047
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