Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an acidic and fibrotic stroma. The extracellular matrix (ECM) causing the fibrosis is primarily formed by pancreatic stellate cells (PSCs). The effects of the altered biomechanics and pH landscape in the pathogenesis of PDAC, however, are p...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuntze, Anna, Goetsch, Ole, Fels, Benedikt, Najder, Karolina, Unger, Andreas, Wilhelmi, Marianne, Sargin, Sarah, Schimmelpfennig, Sandra, Neumann, Ilka, Schwab, Albrecht, Pethő, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033545/
https://www.ncbi.nlm.nih.gov/pubmed/32116794
http://dx.doi.org/10.3389/fphys.2020.00089

Ejemplares similares

Ejemplares similares