Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

Regulation of translation is essential during stress. However, the precise sets of proteins regulated by the key translational stress responses—the integrated stress response (ISR) and mTORC1—remain elusive. We developed multiplexed enhanced protein dynamics (mePROD) proteomics, adding signal amplif...

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Detalles Bibliográficos
Autores principales: Klann, Kevin, Tascher, Georg, Münch, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033560/
https://www.ncbi.nlm.nih.gov/pubmed/31812349
http://dx.doi.org/10.1016/j.molcel.2019.11.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033560/
https://www.ncbi.nlm.nih.gov/pubmed/31812349
http://dx.doi.org/10.1016/j.molcel.2019.11.010

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