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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27me3, respectively. PRC1 and PRC2 exist in different variants and show a complex regulatory cros...

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Detalles Bibliográficos
Autores principales:	Tamburri, Simone, Lavarone, Elisa, Fernández-Pérez, Daniel, Conway, Eric, Zanotti, Marika, Manganaro, Daria, Pasini, Diego
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033561/ https://www.ncbi.nlm.nih.gov/pubmed/31883952 http://dx.doi.org/10.1016/j.molcel.2019.11.021

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