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The regulatory landscapes of developmental genes

Regulatory landscapes have been defined in vertebrates as large DNA segments containing diverse enhancer sequences that produce coherent gene transcription. These genomic platforms integrate multiple cellular signals and hence can trigger pleiotropic expression of developmental genes. Identifying an...

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Detalles Bibliográficos
Autores principales: Bolt, Christopher Chase, Duboule, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033717/
https://www.ncbi.nlm.nih.gov/pubmed/32014867
http://dx.doi.org/10.1242/dev.171736
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author Bolt, Christopher Chase
Duboule, Denis
author_facet Bolt, Christopher Chase
Duboule, Denis
author_sort Bolt, Christopher Chase
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description Regulatory landscapes have been defined in vertebrates as large DNA segments containing diverse enhancer sequences that produce coherent gene transcription. These genomic platforms integrate multiple cellular signals and hence can trigger pleiotropic expression of developmental genes. Identifying and evaluating how these chromatin regions operate may be difficult as the underlying regulatory mechanisms can be as unique as the genes they control. In this brief article and accompanying poster, we discuss some of the ways in which regulatory landscapes operate, illustrating these mechanisms using genes important for vertebrate development as examples. We also highlight some of the techniques available to researchers for analysing regulatory landscapes.
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spelling pubmed-70337172021-02-03 The regulatory landscapes of developmental genes Bolt, Christopher Chase Duboule, Denis Development Development at A Glance Regulatory landscapes have been defined in vertebrates as large DNA segments containing diverse enhancer sequences that produce coherent gene transcription. These genomic platforms integrate multiple cellular signals and hence can trigger pleiotropic expression of developmental genes. Identifying and evaluating how these chromatin regions operate may be difficult as the underlying regulatory mechanisms can be as unique as the genes they control. In this brief article and accompanying poster, we discuss some of the ways in which regulatory landscapes operate, illustrating these mechanisms using genes important for vertebrate development as examples. We also highlight some of the techniques available to researchers for analysing regulatory landscapes. The Company of Biologists Ltd 2020-02-03 /pmc/articles/PMC7033717/ /pubmed/32014867 http://dx.doi.org/10.1242/dev.171736 Text en © 2020. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/4.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Development at A Glance
Bolt, Christopher Chase
Duboule, Denis
The regulatory landscapes of developmental genes
title The regulatory landscapes of developmental genes
title_full The regulatory landscapes of developmental genes
title_fullStr The regulatory landscapes of developmental genes
title_full_unstemmed The regulatory landscapes of developmental genes
title_short The regulatory landscapes of developmental genes
title_sort regulatory landscapes of developmental genes
topic Development at A Glance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033717/
https://www.ncbi.nlm.nih.gov/pubmed/32014867
http://dx.doi.org/10.1242/dev.171736
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