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Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study

BACKGROUND AND PURPOSE: Organ preservation strategies are increasingly being explored for early rectal cancer. This requires revision of target volumes according to disease stage, as well as new guidelines for treatment planning. We conducted an international, multicentre dose planning study to deve...

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Autores principales: Appelt, Ane L., Kerkhof, Ellen M., Nyvang, Lars, Harderwijk, Ernst C., Abbott, Natalie L., Teo, Mark, Peters, Femke P., Kronborg, Camilla J.S., Spindler, Karen-Lise G., Sebag-Montefiore, David, Marijnen, Corrie A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033757/
https://www.ncbi.nlm.nih.gov/pubmed/32095545
http://dx.doi.org/10.1016/j.tipsro.2019.09.001
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author Appelt, Ane L.
Kerkhof, Ellen M.
Nyvang, Lars
Harderwijk, Ernst C.
Abbott, Natalie L.
Teo, Mark
Peters, Femke P.
Kronborg, Camilla J.S.
Spindler, Karen-Lise G.
Sebag-Montefiore, David
Marijnen, Corrie A.M.
author_facet Appelt, Ane L.
Kerkhof, Ellen M.
Nyvang, Lars
Harderwijk, Ernst C.
Abbott, Natalie L.
Teo, Mark
Peters, Femke P.
Kronborg, Camilla J.S.
Spindler, Karen-Lise G.
Sebag-Montefiore, David
Marijnen, Corrie A.M.
author_sort Appelt, Ane L.
collection PubMed
description BACKGROUND AND PURPOSE: Organ preservation strategies are increasingly being explored for early rectal cancer. This requires revision of target volumes according to disease stage, as well as new guidelines for treatment planning. We conducted an international, multicentre dose planning study to develop robust planning objectives for modern radiotherapy of a novel mesorectal-only target volume, as implemented in the STAR-TReC trial (NCT02945566). MATERIALS AND METHODS: The published literature was used to establish relevant dose levels for organ at risk (OAR) plan optimisation. Ten representative patients with early rectal cancer were identified. Treatment scans had mesorectal target volumes as well as bowel cavity, bladder and femoral heads outlined, and were circulated amongst the three participating institutions. Each institution produced plans for short course (SCRT, 5 × 5 Gy) and long course (LCRT, 25 × 2 Gy) treatment, using volumetric modulated arc therapy on different dose planning systems. Optimisation objectives for OARs were established by determining dose metric objectives achievable for ≥90% of plans. RESULTS: Sixty plans, all fulfilling target coverage criteria, were produced. The planning results and literature review suggested optimisation objectives for SCRT: V(10Gy) < 180 cm(3), V(18Gy) < 110 cm(3), V(23Gy) < 85 cm(3) for bowel cavity; V(21Gy) < 15% and V(25Gy) < 5% for bladder; and V(12.5Gy) < 11% for femoral heads. Corresponding objectives for LCRT: V(20Gy) < 180 cm(3), V(30Gy) < 130 cm(3), V(45Gy) < 90 cm(3) for bowel cavity; V(35Gy) < 22% and V(50Gy) < 7% for bladder; and V(25Gy) < 15% for femoral heads. Constraints were validated across all three institutions. CONCLUSION: We utilized a multicentre planning study approach to develop robust planning objectives for mesorectal radiotherapy for early rectal cancer.
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spelling pubmed-70337572020-02-24 Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study Appelt, Ane L. Kerkhof, Ellen M. Nyvang, Lars Harderwijk, Ernst C. Abbott, Natalie L. Teo, Mark Peters, Femke P. Kronborg, Camilla J.S. Spindler, Karen-Lise G. Sebag-Montefiore, David Marijnen, Corrie A.M. Tech Innov Patient Support Radiat Oncol Research article BACKGROUND AND PURPOSE: Organ preservation strategies are increasingly being explored for early rectal cancer. This requires revision of target volumes according to disease stage, as well as new guidelines for treatment planning. We conducted an international, multicentre dose planning study to develop robust planning objectives for modern radiotherapy of a novel mesorectal-only target volume, as implemented in the STAR-TReC trial (NCT02945566). MATERIALS AND METHODS: The published literature was used to establish relevant dose levels for organ at risk (OAR) plan optimisation. Ten representative patients with early rectal cancer were identified. Treatment scans had mesorectal target volumes as well as bowel cavity, bladder and femoral heads outlined, and were circulated amongst the three participating institutions. Each institution produced plans for short course (SCRT, 5 × 5 Gy) and long course (LCRT, 25 × 2 Gy) treatment, using volumetric modulated arc therapy on different dose planning systems. Optimisation objectives for OARs were established by determining dose metric objectives achievable for ≥90% of plans. RESULTS: Sixty plans, all fulfilling target coverage criteria, were produced. The planning results and literature review suggested optimisation objectives for SCRT: V(10Gy) < 180 cm(3), V(18Gy) < 110 cm(3), V(23Gy) < 85 cm(3) for bowel cavity; V(21Gy) < 15% and V(25Gy) < 5% for bladder; and V(12.5Gy) < 11% for femoral heads. Corresponding objectives for LCRT: V(20Gy) < 180 cm(3), V(30Gy) < 130 cm(3), V(45Gy) < 90 cm(3) for bowel cavity; V(35Gy) < 22% and V(50Gy) < 7% for bladder; and V(25Gy) < 15% for femoral heads. Constraints were validated across all three institutions. CONCLUSION: We utilized a multicentre planning study approach to develop robust planning objectives for mesorectal radiotherapy for early rectal cancer. Elsevier 2019-10-15 /pmc/articles/PMC7033757/ /pubmed/32095545 http://dx.doi.org/10.1016/j.tipsro.2019.09.001 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research article
Appelt, Ane L.
Kerkhof, Ellen M.
Nyvang, Lars
Harderwijk, Ernst C.
Abbott, Natalie L.
Teo, Mark
Peters, Femke P.
Kronborg, Camilla J.S.
Spindler, Karen-Lise G.
Sebag-Montefiore, David
Marijnen, Corrie A.M.
Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study
title Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study
title_full Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study
title_fullStr Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study
title_full_unstemmed Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study
title_short Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study
title_sort robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – a multicentre dose planning study
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033757/
https://www.ncbi.nlm.nih.gov/pubmed/32095545
http://dx.doi.org/10.1016/j.tipsro.2019.09.001
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