Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy

BACKGROUND: Trypanosoma cruzi is an intracellular parasite that causes debilitating chronic Chagas cardiomyopathy (CCM), for which there is no effective drug or vaccine. Previously, we demonstrated increased cardiac lipid accumulation and endoplasmic reticulum stress in mice with CCM. Increased endo...

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Detalles Bibliográficos
Autores principales: Ayyappan, Janeesh Plakkal, Lizardo, Kezia, Wang, Sean, Yurkow, Edward, Nagajyothi, Jyothi F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033903/
https://www.ncbi.nlm.nih.gov/pubmed/31973605
http://dx.doi.org/10.1161/JAHA.119.014255

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