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Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study
BACKGROUND: Studies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objecti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033923/ https://www.ncbi.nlm.nih.gov/pubmed/32079534 http://dx.doi.org/10.1186/s12884-020-2755-z |
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author | da Silva, Shana Ginar da Silveira, Mariângela Freitas Bertoldi, Andréa Dâmaso Domingues, Marlos Rodrigues dos Santos, Iná da Silva |
author_facet | da Silva, Shana Ginar da Silveira, Mariângela Freitas Bertoldi, Andréa Dâmaso Domingues, Marlos Rodrigues dos Santos, Iná da Silva |
author_sort | da Silva, Shana Ginar |
collection | PubMed |
description | BACKGROUND: Studies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objective of this study was to compare maternal and child-health outcomes after ART relative to natural conception. METHODS: A population-based birth cohort study was carried out among pregnant women expected to deliver in 2015 in Pelotas, southern Brazil. Maternal outcomes included pregnancy complications and gestational weight gain. Gestational age, weight, intrauterine growth restriction, length and head circumference, and 1-min and 5-min Apgar, as well as health problems at birth and breastfeeding were defined as offspring outcomes. Statistical analyses were performed using linear and logistic regression. G-formula was used to perform mediation analysis. RESULTS: The study included 4252 babies born by spontaneously pregnancies and 23 babies born after ART. Adjusted analyses showed that children conceived from ART presented lower means of gestational age (p = 0.001), birth weight (p = 0.002), length (p < 0.001), and head circumference at birth (p = 0.02). However, more than 90% of the effect of ART over these outcomes was mediated by multiple pregnancy. CONCLUSION: Our findings suggest that the possible negative effect on the child-health outcomes is due mainly to the higher incidence of multiple pregnancies and not because of ART. The reasons for the increase in adverse pregnancy outcomes associated with ART singleton pregnancies are still uncertain and warrants further research. Further large-population studies are needed to confirm these results. |
format | Online Article Text |
id | pubmed-7033923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70339232020-02-27 Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study da Silva, Shana Ginar da Silveira, Mariângela Freitas Bertoldi, Andréa Dâmaso Domingues, Marlos Rodrigues dos Santos, Iná da Silva BMC Pregnancy Childbirth Research Article BACKGROUND: Studies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objective of this study was to compare maternal and child-health outcomes after ART relative to natural conception. METHODS: A population-based birth cohort study was carried out among pregnant women expected to deliver in 2015 in Pelotas, southern Brazil. Maternal outcomes included pregnancy complications and gestational weight gain. Gestational age, weight, intrauterine growth restriction, length and head circumference, and 1-min and 5-min Apgar, as well as health problems at birth and breastfeeding were defined as offspring outcomes. Statistical analyses were performed using linear and logistic regression. G-formula was used to perform mediation analysis. RESULTS: The study included 4252 babies born by spontaneously pregnancies and 23 babies born after ART. Adjusted analyses showed that children conceived from ART presented lower means of gestational age (p = 0.001), birth weight (p = 0.002), length (p < 0.001), and head circumference at birth (p = 0.02). However, more than 90% of the effect of ART over these outcomes was mediated by multiple pregnancy. CONCLUSION: Our findings suggest that the possible negative effect on the child-health outcomes is due mainly to the higher incidence of multiple pregnancies and not because of ART. The reasons for the increase in adverse pregnancy outcomes associated with ART singleton pregnancies are still uncertain and warrants further research. Further large-population studies are needed to confirm these results. BioMed Central 2020-02-21 /pmc/articles/PMC7033923/ /pubmed/32079534 http://dx.doi.org/10.1186/s12884-020-2755-z Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article da Silva, Shana Ginar da Silveira, Mariângela Freitas Bertoldi, Andréa Dâmaso Domingues, Marlos Rodrigues dos Santos, Iná da Silva Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study |
title | Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study |
title_full | Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study |
title_fullStr | Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study |
title_full_unstemmed | Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study |
title_short | Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study |
title_sort | maternal and child-health outcomes in pregnancies following assisted reproductive technology (art): a prospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033923/ https://www.ncbi.nlm.nih.gov/pubmed/32079534 http://dx.doi.org/10.1186/s12884-020-2755-z |
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