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Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings

Congenital toxoplasmosis (CT), the result of a primary infection of pregnant women with Toxoplasma gondii which was transmitted to the fetus, may result in mild to deep injuries occurring in the newborn or later in its development or in adolescence. The visual and cognitive impairment that can resul...

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Autores principales: Bobić, Branko, Villena, Isabelle, Stillwaggon, Eileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034037/
https://www.ncbi.nlm.nih.gov/pubmed/32095628
http://dx.doi.org/10.1016/j.fawpar.2019.e00058
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author Bobić, Branko
Villena, Isabelle
Stillwaggon, Eileen
author_facet Bobić, Branko
Villena, Isabelle
Stillwaggon, Eileen
author_sort Bobić, Branko
collection PubMed
description Congenital toxoplasmosis (CT), the result of a primary infection of pregnant women with Toxoplasma gondii which was transmitted to the fetus, may result in mild to deep injuries occurring in the newborn or later in its development or in adolescence. The visual and cognitive impairment that can result imposes substantial economic costs on the individual and society. Numerous observational studies favor the conclusion that, with preventive measures currently available, it is possible to reduce the incidence of infections in pregnant women, the incidence of fetal infection by preventing transplacental transmission, and the gravity of injury in infected newborns. Treatment of infected newborns can also reduce the severity of consequences and the frequency of their occurrence later in life. Prevention programs, however, are applied in only a few countries; in most countries implementation of a national prevention program has not been considered or has been thought to be too expensive. This article lists the methods of prevention of CT and describes existing national prevention programs in France and Austria. It analyzes the economic costs and benefits of maternal screening for CT prevention and mitigation for society and for health systems. The economic feasibility of implementing national screening in low-prevalence, high-cost countries is illustrated with the example of the United States. New diagnostic tools are discussed and the implication of lower costs is considered, for countries with well-established screening programs as well as those with inadequate prenatal care networks.
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spelling pubmed-70340372020-02-24 Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings Bobić, Branko Villena, Isabelle Stillwaggon, Eileen Food Waterborne Parasitol Article Congenital toxoplasmosis (CT), the result of a primary infection of pregnant women with Toxoplasma gondii which was transmitted to the fetus, may result in mild to deep injuries occurring in the newborn or later in its development or in adolescence. The visual and cognitive impairment that can result imposes substantial economic costs on the individual and society. Numerous observational studies favor the conclusion that, with preventive measures currently available, it is possible to reduce the incidence of infections in pregnant women, the incidence of fetal infection by preventing transplacental transmission, and the gravity of injury in infected newborns. Treatment of infected newborns can also reduce the severity of consequences and the frequency of their occurrence later in life. Prevention programs, however, are applied in only a few countries; in most countries implementation of a national prevention program has not been considered or has been thought to be too expensive. This article lists the methods of prevention of CT and describes existing national prevention programs in France and Austria. It analyzes the economic costs and benefits of maternal screening for CT prevention and mitigation for society and for health systems. The economic feasibility of implementing national screening in low-prevalence, high-cost countries is illustrated with the example of the United States. New diagnostic tools are discussed and the implication of lower costs is considered, for countries with well-established screening programs as well as those with inadequate prenatal care networks. Elsevier 2019-06-01 /pmc/articles/PMC7034037/ /pubmed/32095628 http://dx.doi.org/10.1016/j.fawpar.2019.e00058 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bobić, Branko
Villena, Isabelle
Stillwaggon, Eileen
Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings
title Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings
title_full Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings
title_fullStr Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings
title_full_unstemmed Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings
title_short Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings
title_sort prevention and mitigation of congenital toxoplasmosis. economic costs and benefits in diverse settings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034037/
https://www.ncbi.nlm.nih.gov/pubmed/32095628
http://dx.doi.org/10.1016/j.fawpar.2019.e00058
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