A High-Throughput Screening Identifies MICU1 Targeting Compounds

Mitochondrial Ca(2+) uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to modulate mitochondrial Ca(2+) uptake. Two of them, named...

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Detalles Bibliográficos
Autores principales: Di Marco, Giulia, Vallese, Francesca, Jourde, Benjamin, Bergsdorf, Christian, Sturlese, Mattia, De Mario, Agnese, Techer-Etienne, Valerie, Haasen, Dorothea, Oberhauser, Berndt, Schleeger, Simone, Minetti, Giulia, Moro, Stefano, Rizzuto, Rosario, De Stefani, Diego, Fornaro, Mara, Mammucari, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034061/
https://www.ncbi.nlm.nih.gov/pubmed/32075766
http://dx.doi.org/10.1016/j.celrep.2020.01.081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034061/
https://www.ncbi.nlm.nih.gov/pubmed/32075766
http://dx.doi.org/10.1016/j.celrep.2020.01.081

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