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Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery

Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly...

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Autores principales: Rahmani Del Bakhshayesh, Azizeh, Akbarzadeh, Abolfazl, Alihemmati, Alireza, Tayefi Nasrabadi, Hamid, Montaseri, Azadeh, Davaran, Soodabeh, Abedelahi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034065/
https://www.ncbi.nlm.nih.gov/pubmed/32009480
http://dx.doi.org/10.1080/10717544.2020.1716881
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author Rahmani Del Bakhshayesh, Azizeh
Akbarzadeh, Abolfazl
Alihemmati, Alireza
Tayefi Nasrabadi, Hamid
Montaseri, Azadeh
Davaran, Soodabeh
Abedelahi, Ali
author_facet Rahmani Del Bakhshayesh, Azizeh
Akbarzadeh, Abolfazl
Alihemmati, Alireza
Tayefi Nasrabadi, Hamid
Montaseri, Azadeh
Davaran, Soodabeh
Abedelahi, Ali
author_sort Rahmani Del Bakhshayesh, Azizeh
collection PubMed
description Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PCL) nanoparticles (NPs) offer potential advantages over conventional oral delivery. The purpose of this study is the development of a new type of anti-inflammatory bio-agents containing collagen and PX-loaded NPs, as an example for an oral formulation replacement, for the prolonged release of PX. In this study, the PX was encapsulated in PCL NPs (size 102.7 ± 19.37 nm, encapsulation efficiency 92.83 ± 0.4410) by oil-in-water (o/w) emulsion solvent evaporation method. Nanoparticles were then characterized for entrapment efficiency, percent yield, particle size analysis, morphological characteristics, and in vitro drug release profiles. Eventually, the NPs synthesized with collagen were conjugated so that the NPs were trapped in the collagen sponges using a cross-linker. Finally, biocompatibility tests showed that the anti-inflammatory agents made in this study had no toxic effect on the cells. Based on the results, it appears that PX-loaded PCL NPs along with collagen (PPCLnp-Coll) can be promising for IA administration based on particulate drug delivery for the treatment of arthritis.
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spelling pubmed-70340652020-03-03 Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery Rahmani Del Bakhshayesh, Azizeh Akbarzadeh, Abolfazl Alihemmati, Alireza Tayefi Nasrabadi, Hamid Montaseri, Azadeh Davaran, Soodabeh Abedelahi, Ali Drug Deliv Research Article Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PCL) nanoparticles (NPs) offer potential advantages over conventional oral delivery. The purpose of this study is the development of a new type of anti-inflammatory bio-agents containing collagen and PX-loaded NPs, as an example for an oral formulation replacement, for the prolonged release of PX. In this study, the PX was encapsulated in PCL NPs (size 102.7 ± 19.37 nm, encapsulation efficiency 92.83 ± 0.4410) by oil-in-water (o/w) emulsion solvent evaporation method. Nanoparticles were then characterized for entrapment efficiency, percent yield, particle size analysis, morphological characteristics, and in vitro drug release profiles. Eventually, the NPs synthesized with collagen were conjugated so that the NPs were trapped in the collagen sponges using a cross-linker. Finally, biocompatibility tests showed that the anti-inflammatory agents made in this study had no toxic effect on the cells. Based on the results, it appears that PX-loaded PCL NPs along with collagen (PPCLnp-Coll) can be promising for IA administration based on particulate drug delivery for the treatment of arthritis. Taylor & Francis 2020-02-03 /pmc/articles/PMC7034065/ /pubmed/32009480 http://dx.doi.org/10.1080/10717544.2020.1716881 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rahmani Del Bakhshayesh, Azizeh
Akbarzadeh, Abolfazl
Alihemmati, Alireza
Tayefi Nasrabadi, Hamid
Montaseri, Azadeh
Davaran, Soodabeh
Abedelahi, Ali
Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
title Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
title_full Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
title_fullStr Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
title_full_unstemmed Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
title_short Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
title_sort preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained nsaid delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034065/
https://www.ncbi.nlm.nih.gov/pubmed/32009480
http://dx.doi.org/10.1080/10717544.2020.1716881
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