Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism

CONTEXT: Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs. However, the effect of verapamil on the pharmacokinetics of HCPT was no...

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Detalles Bibliográficos
Autores principales: Xing, Hua, Luo, Xiao, Li, Yang, Fan, Chunni, Liu, Ning, Cui, Chunguo, Li, Wenjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034088/
https://www.ncbi.nlm.nih.gov/pubmed/31990625
http://dx.doi.org/10.1080/13880209.2020.1717550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034088/
https://www.ncbi.nlm.nih.gov/pubmed/31990625
http://dx.doi.org/10.1080/13880209.2020.1717550

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