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Insights into channel modulation mechanism of RYR1 mutants using Ca(2+) imaging and molecular dynamics

Type 1 ryanodine receptor (RYR1) is a Ca(2+) release channel in the sarcoplasmic reticulum in skeletal muscle and plays an important role in excitation–contraction coupling. Mutations in the RYR1 gene cause severe muscle diseases such as malignant hyperthermia (MH), which is a disorder of CICR via R...

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Detalles Bibliográficos
Autores principales:	Yamazawa, Toshiko, Ogawa, Haruo, Murayama, Takashi, Yamaguchi, Maki, Oyamada, Hideto, Suzuki, Junji, Kurebayashi, Nagomi, Kanemaru, Kazunori, Oguchi, Katsuji, Sakurai, Takashi, Iino, Masamitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034096/ https://www.ncbi.nlm.nih.gov/pubmed/31841587 http://dx.doi.org/10.1085/jgp.201812235

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