Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification

PURPOSE: Does perioperative use of Rho-Kinase (ROCK) inhibitors have beneficial effect on corneal endothelial cells after phacoemulsification? SETTING: This study was conducted at King Abdulaziz University Hospital in Riyadh. DESIGN: This was a prospective study assessing the effect of ROCK inhibito...

Descripción completa

Detalles Bibliográficos
Autores principales: Alkharashi, Majed, AlAbbasi, Omar, Magliyah, Moustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034144/
https://www.ncbi.nlm.nih.gov/pubmed/32153339
http://dx.doi.org/10.4103/meajo.MEAJO_27_19
_version_ 1783499818534961152
author Alkharashi, Majed
AlAbbasi, Omar
Magliyah, Moustafa
author_facet Alkharashi, Majed
AlAbbasi, Omar
Magliyah, Moustafa
author_sort Alkharashi, Majed
collection PubMed
description PURPOSE: Does perioperative use of Rho-Kinase (ROCK) inhibitors have beneficial effect on corneal endothelial cells after phacoemulsification? SETTING: This study was conducted at King Abdulaziz University Hospital in Riyadh. DESIGN: This was a prospective study assessing the effect of ROCK inhibitors on corneal endothelium after phacoemulsification. METHODOLOGY: Three patients have used ROCK inhibitor 1 day before and 1 week after phacoemulsification surgery, and specular microscopy and Pentacam were done preoperatively and 3 months postoperatively. RESULTS: Endothelial cell density decreased to 11.3%, 9.45%, and 4.09% in eyes with ROCK inhibitors and 23.9% in one eye without ROCK inhibitor. CONCLUSION: Perioperative ROCK inhibitor use has a possible protective effect on corneal endothelium.
format Online
Article
Text
id pubmed-7034144
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-70341442020-03-09 Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification Alkharashi, Majed AlAbbasi, Omar Magliyah, Moustafa Middle East Afr J Ophthalmol Case Report PURPOSE: Does perioperative use of Rho-Kinase (ROCK) inhibitors have beneficial effect on corneal endothelial cells after phacoemulsification? SETTING: This study was conducted at King Abdulaziz University Hospital in Riyadh. DESIGN: This was a prospective study assessing the effect of ROCK inhibitors on corneal endothelium after phacoemulsification. METHODOLOGY: Three patients have used ROCK inhibitor 1 day before and 1 week after phacoemulsification surgery, and specular microscopy and Pentacam were done preoperatively and 3 months postoperatively. RESULTS: Endothelial cell density decreased to 11.3%, 9.45%, and 4.09% in eyes with ROCK inhibitors and 23.9% in one eye without ROCK inhibitor. CONCLUSION: Perioperative ROCK inhibitor use has a possible protective effect on corneal endothelium. Wolters Kluwer - Medknow 2020-01-29 /pmc/articles/PMC7034144/ /pubmed/32153339 http://dx.doi.org/10.4103/meajo.MEAJO_27_19 Text en Copyright: © 2020 Middle East African Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Alkharashi, Majed
AlAbbasi, Omar
Magliyah, Moustafa
Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification
title Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification
title_full Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification
title_fullStr Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification
title_full_unstemmed Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification
title_short Perioperative Use of Rho-Kinase Inhibitors has Beneficial Effect on Corneal Endothelium after Phacoemulsification
title_sort perioperative use of rho-kinase inhibitors has beneficial effect on corneal endothelium after phacoemulsification
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034144/
https://www.ncbi.nlm.nih.gov/pubmed/32153339
http://dx.doi.org/10.4103/meajo.MEAJO_27_19
work_keys_str_mv AT alkharashimajed perioperativeuseofrhokinaseinhibitorshasbeneficialeffectoncornealendotheliumafterphacoemulsification
AT alabbasiomar perioperativeuseofrhokinaseinhibitorshasbeneficialeffectoncornealendotheliumafterphacoemulsification
AT magliyahmoustafa perioperativeuseofrhokinaseinhibitorshasbeneficialeffectoncornealendotheliumafterphacoemulsification

Ejemplares similares