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Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis

Tuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate...

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Autores principales: Choreño-Parra, José Alberto, Weinstein, León Islas, Yunis, Edmond J., Zúñiga, Joaquín, Hernández-Pando, Rogelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034257/
https://www.ncbi.nlm.nih.gov/pubmed/32117325
http://dx.doi.org/10.3389/fimmu.2020.00226
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author Choreño-Parra, José Alberto
Weinstein, León Islas
Yunis, Edmond J.
Zúñiga, Joaquín
Hernández-Pando, Rogelio
author_facet Choreño-Parra, José Alberto
Weinstein, León Islas
Yunis, Edmond J.
Zúñiga, Joaquín
Hernández-Pando, Rogelio
author_sort Choreño-Parra, José Alberto
collection PubMed
description Tuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate of protection in TB. Nonetheless, the demonstration that other cellular subsets offer protective memory responses against Mycobacterium tuberculosis (Mtb) is emerging. Among these are memory-like features of macrophages, myeloid cell precursors, natural killer (NK) cells, and innate lymphoid cells (ILCs). Additionally, the dynamics of B cell memory responses have been recently characterized at different stages of the clinical spectrum of Mtb infection, suggesting a role for B cells in human TB. A better understanding of the immune mechanisms underlying such responses is crucial to better comprehend protective immunity in TB. Furthermore, targeting immune compartments other than CD4+ T cells in TB vaccine strategies may benefit a significant proportion of patients co-infected with Mtb and the human immunodeficiency virus (HIV). Here, we summarize the memory responses of innate immune cells and B cells against Mtb and propose them as novel correlates of protection that could be harnessed in future vaccine development programs.
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spelling pubmed-70342572020-02-28 Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis Choreño-Parra, José Alberto Weinstein, León Islas Yunis, Edmond J. Zúñiga, Joaquín Hernández-Pando, Rogelio Front Immunol Immunology Tuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate of protection in TB. Nonetheless, the demonstration that other cellular subsets offer protective memory responses against Mycobacterium tuberculosis (Mtb) is emerging. Among these are memory-like features of macrophages, myeloid cell precursors, natural killer (NK) cells, and innate lymphoid cells (ILCs). Additionally, the dynamics of B cell memory responses have been recently characterized at different stages of the clinical spectrum of Mtb infection, suggesting a role for B cells in human TB. A better understanding of the immune mechanisms underlying such responses is crucial to better comprehend protective immunity in TB. Furthermore, targeting immune compartments other than CD4+ T cells in TB vaccine strategies may benefit a significant proportion of patients co-infected with Mtb and the human immunodeficiency virus (HIV). Here, we summarize the memory responses of innate immune cells and B cells against Mtb and propose them as novel correlates of protection that could be harnessed in future vaccine development programs. Frontiers Media S.A. 2020-02-14 /pmc/articles/PMC7034257/ /pubmed/32117325 http://dx.doi.org/10.3389/fimmu.2020.00226 Text en Copyright © 2020 Choreño-Parra, Weinstein, Yunis, Zúñiga and Hernández-Pando. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Choreño-Parra, José Alberto
Weinstein, León Islas
Yunis, Edmond J.
Zúñiga, Joaquín
Hernández-Pando, Rogelio
Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
title Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
title_full Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
title_fullStr Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
title_full_unstemmed Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
title_short Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
title_sort thinking outside the box: innate- and b cell-memory responses as novel protective mechanisms against tuberculosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034257/
https://www.ncbi.nlm.nih.gov/pubmed/32117325
http://dx.doi.org/10.3389/fimmu.2020.00226
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