Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

OBJECTIVE: The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic colitis and probed mechanisms of IL22-mediated regulation of...

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Detalles Bibliográficos
Autores principales: Powell, Nick, Pantazi, Eirini, Pavlidis, Polychronis, Tsakmaki, Anastasia, Li, Katherine, Yang, Feifei, Parker, Aimee, Pin, Carmen, Cozzetto, Domenico, Minns, Danielle, Stolarczyk, Emilie, Saveljeva, Svetlana, Mohamed, Rami, Lavender, Paul, Afzali, Behdad, Digby-Bell, Jonathan, Tjir-Li, Tsui, Kaser, Arthur, Friedman, Joshua, MacDonald, Thomas T, Bewick, Gavin A, Lord, Graham M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Recent Advances in Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034350/
https://www.ncbi.nlm.nih.gov/pubmed/31792136
http://dx.doi.org/10.1136/gutjnl-2019-318483

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