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High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE). METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 2...

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Detalles Bibliográficos
Autores principales:	Reid, Sarah, Alexsson, Andrei, Frodlund, Martina, Morris, David, Sandling, Johanna K, Bolin, Karin, Svenungsson, Elisabet, Jönsen, Andreas, Bengtsson, Christine, Gunnarsson, Iva, Illescas Rodriguez, Vera, Bengtsson, Anders, Arve, Sabine, Rantapää-Dahlqvist, Solbritt, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Sjöwall, Christopher, Vyse, Timothy James, Rönnblom, Lars, Leonard, Dag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Systemic Lupus Erythematosus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034364/ https://www.ncbi.nlm.nih.gov/pubmed/31826855 http://dx.doi.org/10.1136/annrheumdis-2019-216227

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