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Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review

OBJECTIVE: To examine the effect of age on procedural and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) lesions. METHODS: Literature search was conducted across PubMed, Google Scholar and Web of science, databases till March 2019....

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Autores principales: Lateef, Noman, Ahsan, Muhammad Junaid, Fazeel, Hafiz Muhammad, Haseeb, Abdul, Latif, Azka, Kousa, Omar, Mirza, Mohsin, Holmberg, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034474/
https://www.ncbi.nlm.nih.gov/pubmed/32128055
http://dx.doi.org/10.1080/20009666.2020.1719731
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author Lateef, Noman
Ahsan, Muhammad Junaid
Fazeel, Hafiz Muhammad
Haseeb, Abdul
Latif, Azka
Kousa, Omar
Mirza, Mohsin
Holmberg, Mark
author_facet Lateef, Noman
Ahsan, Muhammad Junaid
Fazeel, Hafiz Muhammad
Haseeb, Abdul
Latif, Azka
Kousa, Omar
Mirza, Mohsin
Holmberg, Mark
author_sort Lateef, Noman
collection PubMed
description OBJECTIVE: To examine the effect of age on procedural and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) lesions. METHODS: Literature search was conducted across PubMed, Google Scholar and Web of science, databases till March 2019. RESULTS: Seven studies including 7671 patients with an overall follow-up period of 1.5 to 5 years were included in our review. A total of 6299/1372 patients were included in non-elderly and elderly groups, respectively, with mean age and 67%/61% male patients. CTO-PCI was similarly successful in younger and older patients (82.8%, n = 5070 vs. 78.1%, n = 1010). The incidence of short-term outcomes was low across the studies and comparable between the two groups (all-cause mortality: 0.4% younger vs. 0.85% elderly, cerebrovascular accidents: 0.3% vs. 0.4%, major adverse cardiovascular events (MACE): 1.53% vs. 3.72% and major bleeding: 0.57% vs. 2.18%). Long-term outcomes including all-cause mortality (8.89% vs. 29.5%), cardiac mortality (3.72% vs. 15%) and MACE (24.9% vs. 40%) occurred with a higher incidence in elderly patients. When results were segregated according to the success of CTO-PCI, reduced clinical events were noted with successful revascularization in either age group. CONCLUSION: Compared with the younger age group, CTO-PCI in elderly patients is safe and feasible with a comparable incidence of short-term outcomes. In either population, the incidence of long-term outcomes including survival remains a concern but when successful, CTO-PCI may be associated with improvement in terms of multiple patient-important clinical end-points.
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spelling pubmed-70344742020-03-03 Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review Lateef, Noman Ahsan, Muhammad Junaid Fazeel, Hafiz Muhammad Haseeb, Abdul Latif, Azka Kousa, Omar Mirza, Mohsin Holmberg, Mark J Community Hosp Intern Med Perspect Review Article OBJECTIVE: To examine the effect of age on procedural and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) lesions. METHODS: Literature search was conducted across PubMed, Google Scholar and Web of science, databases till March 2019. RESULTS: Seven studies including 7671 patients with an overall follow-up period of 1.5 to 5 years were included in our review. A total of 6299/1372 patients were included in non-elderly and elderly groups, respectively, with mean age and 67%/61% male patients. CTO-PCI was similarly successful in younger and older patients (82.8%, n = 5070 vs. 78.1%, n = 1010). The incidence of short-term outcomes was low across the studies and comparable between the two groups (all-cause mortality: 0.4% younger vs. 0.85% elderly, cerebrovascular accidents: 0.3% vs. 0.4%, major adverse cardiovascular events (MACE): 1.53% vs. 3.72% and major bleeding: 0.57% vs. 2.18%). Long-term outcomes including all-cause mortality (8.89% vs. 29.5%), cardiac mortality (3.72% vs. 15%) and MACE (24.9% vs. 40%) occurred with a higher incidence in elderly patients. When results were segregated according to the success of CTO-PCI, reduced clinical events were noted with successful revascularization in either age group. CONCLUSION: Compared with the younger age group, CTO-PCI in elderly patients is safe and feasible with a comparable incidence of short-term outcomes. In either population, the incidence of long-term outcomes including survival remains a concern but when successful, CTO-PCI may be associated with improvement in terms of multiple patient-important clinical end-points. Taylor & Francis 2020-01-02 /pmc/articles/PMC7034474/ /pubmed/32128055 http://dx.doi.org/10.1080/20009666.2020.1719731 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lateef, Noman
Ahsan, Muhammad Junaid
Fazeel, Hafiz Muhammad
Haseeb, Abdul
Latif, Azka
Kousa, Omar
Mirza, Mohsin
Holmberg, Mark
Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
title Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
title_full Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
title_fullStr Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
title_full_unstemmed Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
title_short Percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
title_sort percutaneous coronary intervention for chronic total occlusion in patients aged <75 years versus ≥75 years: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034474/
https://www.ncbi.nlm.nih.gov/pubmed/32128055
http://dx.doi.org/10.1080/20009666.2020.1719731
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