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An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis

The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA(A)‐R) encephalitis by next‐...

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Autores principales: Bracher, Aline, Alcalá, Carmen, Ferrer, Jaime, Melzer, Nico, Hohlfeld, Reinhard, Casanova, Bonaventura, Beltrán, Eduardo, Dornmair, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034500/
https://www.ncbi.nlm.nih.gov/pubmed/31943946
http://dx.doi.org/10.1002/acn3.50974
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author Bracher, Aline
Alcalá, Carmen
Ferrer, Jaime
Melzer, Nico
Hohlfeld, Reinhard
Casanova, Bonaventura
Beltrán, Eduardo
Dornmair, Klaus
author_facet Bracher, Aline
Alcalá, Carmen
Ferrer, Jaime
Melzer, Nico
Hohlfeld, Reinhard
Casanova, Bonaventura
Beltrán, Eduardo
Dornmair, Klaus
author_sort Bracher, Aline
collection PubMed
description The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA(A)‐R) encephalitis by next‐generation sequencing and single‐cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo‐insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis.
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spelling pubmed-70345002020-02-27 An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis Bracher, Aline Alcalá, Carmen Ferrer, Jaime Melzer, Nico Hohlfeld, Reinhard Casanova, Bonaventura Beltrán, Eduardo Dornmair, Klaus Ann Clin Transl Neurol Brief Communications The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA(A)‐R) encephalitis by next‐generation sequencing and single‐cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo‐insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis. John Wiley and Sons Inc. 2020-01-14 /pmc/articles/PMC7034500/ /pubmed/31943946 http://dx.doi.org/10.1002/acn3.50974 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Bracher, Aline
Alcalá, Carmen
Ferrer, Jaime
Melzer, Nico
Hohlfeld, Reinhard
Casanova, Bonaventura
Beltrán, Eduardo
Dornmair, Klaus
An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
title An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
title_full An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
title_fullStr An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
title_full_unstemmed An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
title_short An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
title_sort expanded parenchymal cd8+ t cell clone in gaba(a) receptor encephalitis
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034500/
https://www.ncbi.nlm.nih.gov/pubmed/31943946
http://dx.doi.org/10.1002/acn3.50974
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