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An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis
The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA(A)‐R) encephalitis by next‐...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034500/ https://www.ncbi.nlm.nih.gov/pubmed/31943946 http://dx.doi.org/10.1002/acn3.50974 |
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author | Bracher, Aline Alcalá, Carmen Ferrer, Jaime Melzer, Nico Hohlfeld, Reinhard Casanova, Bonaventura Beltrán, Eduardo Dornmair, Klaus |
author_facet | Bracher, Aline Alcalá, Carmen Ferrer, Jaime Melzer, Nico Hohlfeld, Reinhard Casanova, Bonaventura Beltrán, Eduardo Dornmair, Klaus |
author_sort | Bracher, Aline |
collection | PubMed |
description | The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA(A)‐R) encephalitis by next‐generation sequencing and single‐cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo‐insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis. |
format | Online Article Text |
id | pubmed-7034500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70345002020-02-27 An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis Bracher, Aline Alcalá, Carmen Ferrer, Jaime Melzer, Nico Hohlfeld, Reinhard Casanova, Bonaventura Beltrán, Eduardo Dornmair, Klaus Ann Clin Transl Neurol Brief Communications The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA(A)‐R) encephalitis by next‐generation sequencing and single‐cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo‐insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis. John Wiley and Sons Inc. 2020-01-14 /pmc/articles/PMC7034500/ /pubmed/31943946 http://dx.doi.org/10.1002/acn3.50974 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communications Bracher, Aline Alcalá, Carmen Ferrer, Jaime Melzer, Nico Hohlfeld, Reinhard Casanova, Bonaventura Beltrán, Eduardo Dornmair, Klaus An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis |
title | An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis |
title_full | An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis |
title_fullStr | An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis |
title_full_unstemmed | An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis |
title_short | An expanded parenchymal CD8+ T cell clone in GABA(A) receptor encephalitis |
title_sort | expanded parenchymal cd8+ t cell clone in gaba(a) receptor encephalitis |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034500/ https://www.ncbi.nlm.nih.gov/pubmed/31943946 http://dx.doi.org/10.1002/acn3.50974 |
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