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Early phase 2 trial of TAS‐205 in patients with Duchenne muscular dystrophy

OBJECTIVE: Duchenne muscular dystrophy (DMD) is a progressive muscular disease characterized by chronic cycles of inflammatory and necrotic processes. Prostaglandin D(2) (PGD(2)) is produced by hematopoietic PGD synthase (HPGDS), which is pathologically implicated in muscle necrosis. This randomized...

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Detalles Bibliográficos
Autores principales: Komaki, Hirofumi, Maegaki, Yoshihiro, Matsumura, Tsuyoshi, Shiraishi, Kazuhiro, Awano, Hiroyuki, Nakamura, Akinori, Kinoshita, Satoru, Ogata, Katsuhisa, Ishigaki, Keiko, Saitoh, Shinji, Funato, Michinori, Kuru, Satoshi, Nakayama, Takahiro, Iwata, Yasuyuki, Yajima, Hiroyuki, Takeda, Shin’ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034509/
https://www.ncbi.nlm.nih.gov/pubmed/31957953
http://dx.doi.org/10.1002/acn3.50978