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The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study
We investigated the effect of the maximum standardized uptake value (SUV(max)) and peritoneal dissemination derived from (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) imaging on prognosis in patients with recurrent ovarian cancer. We retrospectively a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034678/ https://www.ncbi.nlm.nih.gov/pubmed/32080121 http://dx.doi.org/10.1097/MD.0000000000019228 |
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author | Jiang, Yuanyuan Hou, Guozhu Wu, Fengyu Zhu, Zhaohui Zhang, Wei Cheng, Wuying |
author_facet | Jiang, Yuanyuan Hou, Guozhu Wu, Fengyu Zhu, Zhaohui Zhang, Wei Cheng, Wuying |
author_sort | Jiang, Yuanyuan |
collection | PubMed |
description | We investigated the effect of the maximum standardized uptake value (SUV(max)) and peritoneal dissemination derived from (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) imaging on prognosis in patients with recurrent ovarian cancer. We retrospectively analyzed 145 patients with suspected recurrent ovarian cancer who had undergone (18)F-FDG PET/CT scans after cytoreductive surgery and chemotherapy. The degree of peritoneal spread was classified as localized (1–3 FDG foci) or diffuse (>3 FDG foci). Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values for predicting recurrence. A total of 145 patients were retrospectively reviewed in this study. 29 patients were excluded as their follow-up results were not available. One hundred sixteen patients were included in the final analysis. The median duration of progression-free survival was 14 months. (18)F-FDG PET/CT detected peritoneal carcinomatosis in 82 patients. With a cut-off SUV(max) of 2.0 obtained from the ROC curve analysis, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of SUV(max) of peritoneal carcinomatosis for predicting recurrence were 77.6%, 87.5%, 65.1%, 97.4%, and 38.9%, respectively. The area under the curve was 0.85. In a multivariate analysis, significant independent prognostic variables were SUV(max) of peritoneal disease, peritoneal dissemination, and CA125 levels. In patients with peritoneal involvement, the Kaplan-Meier survival curves showed significantly longer PFS in those with localized disease. SUV(max) of peritoneal disease is valuable in predicting the recurrence of ovarian cancer. SUV(max) of peritoneal disease, peritoneal dissemination and CA125 level could be used as independent prognostic factors for ovarian cancer patients. |
format | Online Article Text |
id | pubmed-7034678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-70346782020-03-10 The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study Jiang, Yuanyuan Hou, Guozhu Wu, Fengyu Zhu, Zhaohui Zhang, Wei Cheng, Wuying Medicine (Baltimore) 5600 We investigated the effect of the maximum standardized uptake value (SUV(max)) and peritoneal dissemination derived from (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) imaging on prognosis in patients with recurrent ovarian cancer. We retrospectively analyzed 145 patients with suspected recurrent ovarian cancer who had undergone (18)F-FDG PET/CT scans after cytoreductive surgery and chemotherapy. The degree of peritoneal spread was classified as localized (1–3 FDG foci) or diffuse (>3 FDG foci). Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values for predicting recurrence. A total of 145 patients were retrospectively reviewed in this study. 29 patients were excluded as their follow-up results were not available. One hundred sixteen patients were included in the final analysis. The median duration of progression-free survival was 14 months. (18)F-FDG PET/CT detected peritoneal carcinomatosis in 82 patients. With a cut-off SUV(max) of 2.0 obtained from the ROC curve analysis, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of SUV(max) of peritoneal carcinomatosis for predicting recurrence were 77.6%, 87.5%, 65.1%, 97.4%, and 38.9%, respectively. The area under the curve was 0.85. In a multivariate analysis, significant independent prognostic variables were SUV(max) of peritoneal disease, peritoneal dissemination, and CA125 levels. In patients with peritoneal involvement, the Kaplan-Meier survival curves showed significantly longer PFS in those with localized disease. SUV(max) of peritoneal disease is valuable in predicting the recurrence of ovarian cancer. SUV(max) of peritoneal disease, peritoneal dissemination and CA125 level could be used as independent prognostic factors for ovarian cancer patients. Wolters Kluwer Health 2020-02-21 /pmc/articles/PMC7034678/ /pubmed/32080121 http://dx.doi.org/10.1097/MD.0000000000019228 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5600 Jiang, Yuanyuan Hou, Guozhu Wu, Fengyu Zhu, Zhaohui Zhang, Wei Cheng, Wuying The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study |
title | The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study |
title_full | The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study |
title_fullStr | The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study |
title_full_unstemmed | The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study |
title_short | The maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: A retrospective clinical study |
title_sort | maximum standardized uptake value and extent of peritoneal involvement may predict the prognosis of patients with recurrent ovarian cancer after primary treatment: a retrospective clinical study |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034678/ https://www.ncbi.nlm.nih.gov/pubmed/32080121 http://dx.doi.org/10.1097/MD.0000000000019228 |
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