Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis

Breast cancer is a molecularly heterogeneous disorder associated with high lethal malignant tumors among women worldwide. Genetic factors play an important role in breast cancer development. Several single nucleotide polymorphisms in the 8q24 region associated with risk of breast cancer have been id...

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Autores principales: Wang, Xuedong, He, Xian, Guo, Hui, Tong, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
4400
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034712/
https://www.ncbi.nlm.nih.gov/pubmed/32080114
http://dx.doi.org/10.1097/MD.0000000000019217
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author Wang, Xuedong
He, Xian
Guo, Hui
Tong, Yu
author_facet Wang, Xuedong
He, Xian
Guo, Hui
Tong, Yu
author_sort Wang, Xuedong
collection PubMed
description Breast cancer is a molecularly heterogeneous disorder associated with high lethal malignant tumors among women worldwide. Genetic factors play an important role in breast cancer development. Several single nucleotide polymorphisms in the 8q24 region associated with risk of breast cancer have been identified. Fifteen studies including 32,955 cases and 43,716 controls were collected to conduct a meta-analysis to evaluate the associations between variants in 8q24 region and risk of breast cancer. Our study showed that only rs13281615 is associated with breast cancer risk in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the role of the 8q24 variants in the development of breast cancer.
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spelling pubmed-70347122020-03-10 Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis Wang, Xuedong He, Xian Guo, Hui Tong, Yu Medicine (Baltimore) 4400 Breast cancer is a molecularly heterogeneous disorder associated with high lethal malignant tumors among women worldwide. Genetic factors play an important role in breast cancer development. Several single nucleotide polymorphisms in the 8q24 region associated with risk of breast cancer have been identified. Fifteen studies including 32,955 cases and 43,716 controls were collected to conduct a meta-analysis to evaluate the associations between variants in 8q24 region and risk of breast cancer. Our study showed that only rs13281615 is associated with breast cancer risk in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the role of the 8q24 variants in the development of breast cancer. Wolters Kluwer Health 2020-02-21 /pmc/articles/PMC7034712/ /pubmed/32080114 http://dx.doi.org/10.1097/MD.0000000000019217 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4400
Wang, Xuedong
He, Xian
Guo, Hui
Tong, Yu
Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis
title Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis
title_full Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis
title_fullStr Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis
title_full_unstemmed Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis
title_short Variants in the 8q24 region associated with risk of breast cancer: Systematic research synopsis and meta-analysis
title_sort variants in the 8q24 region associated with risk of breast cancer: systematic research synopsis and meta-analysis
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034712/
https://www.ncbi.nlm.nih.gov/pubmed/32080114
http://dx.doi.org/10.1097/MD.0000000000019217
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