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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca(2+), and receptor binding

The Ebola virus (EBOV) envelope glycoprotein (GP) is a membrane fusion machine required for virus entry into cells. Following endocytosis of EBOV, the GP1 domain is cleaved by cellular cathepsins in acidic endosomes, removing the glycan cap and exposing a binding site for the Niemann-Pick C1 (NPC1)...

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Detalles Bibliográficos
Autores principales:	Das, Dibyendu Kumar, Bulow, Uriel, Diehl, William E., Durham, Natasha D., Senjobe, Fernando, Chandran, Kartik, Luban, Jeremy, Munro, James B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034923/ https://www.ncbi.nlm.nih.gov/pubmed/32040508 http://dx.doi.org/10.1371/journal.pbio.3000626

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