Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling

[Image: see text] A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-(13/14)C] alkyl amides, thereby reducing radioactive waste, and handling of radio...

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Detalles Bibliográficos
Autores principales: Sardana, Malvika, Bergman, Joakim, Ericsson, Cecilia, Kingston, Lee P., Schou, Magnus, Dugave, Christophe, Audisio, Davide, Elmore, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034930/
https://www.ncbi.nlm.nih.gov/pubmed/31769679
http://dx.doi.org/10.1021/acs.joc.9b02575
Descripción
Sumario:[Image: see text] A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-(13/14)C] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.

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