Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling

[Image: see text] A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-(13/14)C] alkyl amides, thereby reducing radioactive waste, and handling of radio...

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Autores principales: Sardana, Malvika, Bergman, Joakim, Ericsson, Cecilia, Kingston, Lee P., Schou, Magnus, Dugave, Christophe, Audisio, Davide, Elmore, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034930/
https://www.ncbi.nlm.nih.gov/pubmed/31769679
http://dx.doi.org/10.1021/acs.joc.9b02575
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author Sardana, Malvika
Bergman, Joakim
Ericsson, Cecilia
Kingston, Lee P.
Schou, Magnus
Dugave, Christophe
Audisio, Davide
Elmore, Charles S.
author_facet Sardana, Malvika
Bergman, Joakim
Ericsson, Cecilia
Kingston, Lee P.
Schou, Magnus
Dugave, Christophe
Audisio, Davide
Elmore, Charles S.
author_sort Sardana, Malvika
collection PubMed
description [Image: see text] A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-(13/14)C] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.
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spelling pubmed-70349302020-02-24 Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling Sardana, Malvika Bergman, Joakim Ericsson, Cecilia Kingston, Lee P. Schou, Magnus Dugave, Christophe Audisio, Davide Elmore, Charles S. J Org Chem [Image: see text] A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-(13/14)C] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides. American Chemical Society 2019-11-26 2019-12-20 /pmc/articles/PMC7034930/ /pubmed/31769679 http://dx.doi.org/10.1021/acs.joc.9b02575 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sardana, Malvika
Bergman, Joakim
Ericsson, Cecilia
Kingston, Lee P.
Schou, Magnus
Dugave, Christophe
Audisio, Davide
Elmore, Charles S.
Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling
title Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling
title_full Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling
title_fullStr Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling
title_full_unstemmed Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling
title_short Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling
title_sort visible-light-enabled aminocarbonylation of unactivated alkyl iodides with stoichiometric carbon monoxide for application on late-stage carbon isotope labeling
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034930/
https://www.ncbi.nlm.nih.gov/pubmed/31769679
http://dx.doi.org/10.1021/acs.joc.9b02575
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