Cargando…

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

The HIV-1 capsid (CA) protein plays crucial roles in both early and late stages of the viral life cycle, which has intrigued researchers to target it to develop anti-HIV drugs. Accordingly, in this research, we report the design, synthesis and biological evaluation of a series of novel phenylalanine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xiangyi, Wu, Gaochan, Zalloum, Waleed A., Meuser, Megan E., Dick, Alexej, Sun, Lin, Chen, Chin-Ho, Kang, Dongwei, Jing, Lanlan, Jia, Ruifang, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034945/ https://www.ncbi.nlm.nih.gov/pubmed/32089839 http://dx.doi.org/10.1039/c9ra05869a

Ejemplares similares

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators
por: Xu, Shujing, et al.
Publicado: (2022)

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction
por: Ji, Xiangkai, et al.
Publicado: (2022)

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation
por: Dick, Alexej, et al.
Publicado: (2022)

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators
por: Zhang, Xujie, et al.
Publicado: (2022)

Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
por: Beyki, Khalil, et al.
Publicado: (2016)

Synthesis of Chiral 1,4-Disubstituted-1,2,3-Triazole Derivatives from Amino Acids
por: Klein, Michael, et al.
Publicado: (2009)

Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona—Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers
por: Jernei, Tamás, et al.
Publicado: (2019)

Structure, Function, and Interactions of the HIV-1 Capsid Protein
por: Rossi, Eric, et al.
Publicado: (2021)

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity
por: Rečnik, Lisa-Maria, et al.
Publicado: (2020)

Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases
por: Algieri, Vincenzo, et al.
Publicado: (2022)

1,4-Disubstituted 1H-1,2,3-Triazoles for Renal Diseases: Studies of Viability, Anti-Inflammatory, and Antioxidant Activities
por: Cheng, Ching-Yi, et al.
Publicado: (2020)

1,4-Disubstituted 1H-1,2,3-Triazole Containing Peptidotriazolamers: A New Class of Peptidomimetics With Interesting Foldamer Properties
por: Schröder, David C., et al.
Publicado: (2019)

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

Recent Advances in HIV-1 Gag Inhibitor Design and Development
por: Dick, Alexej, et al.
Publicado: (2020)

A Green Ultrasound Synthesis, Characterization and Antibacterial Evaluation of 1,4-Disubstituted 1,2,3-Triazoles Tethering Bioactive Benzothiazole Nucleus
por: Rezki, Nadjet
Publicado: (2016)

Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs
por: Abuduaini, Tuniyazi, et al.
Publicado: (2021)

Natural phosphate-supported Cu(ii), an efficient and recyclable catalyst for the synthesis of xanthene and 1,4-disubstituted-1,2,3-triazole derivatives
por: Amini, Abbas, et al.
Publicado: (2018)

Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions
por: Dick, Alexej, et al.
Publicado: (2021)

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes
por: Israr, Muhammad, et al.
Publicado: (2018)

1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in Leishmania amazonensis Promastigote: An in Vitro Antileishmanial and in Silico Pharmacokinetic Study
por: Almeida-Souza, Fernando, et al.
Publicado: (2020)

Synthesis, antibacterial activity and molecular docking study of vanillin derived 1,4-disubstituted 1,2,3-triazoles as inhibitors of bacterial DNA synthesis
por: Hussain, Mumtaz, et al.
Publicado: (2019)

Efficient stabilisation of a dihydrogenphosphate tetramer and a dihydrogenpyrophosphate dimer by a cyclic pseudopeptide containing 1,4-disubstituted 1,2,3-triazole moieties
por: Mungalpara, Disha, et al.
Publicado: (2017)

Copper-catalyzed in situ oxidative-coupling for one-pot synthesis of 5-aryl-1,4-disubstituted 1,2,3-triazoles under mild conditions
por: Wang, Chao, et al.
Publicado: (2021)

Synthesis of Dense 1,2,3-Triazole Oligomers Consisting Preferentially of 1,5-Disubstituted Units via Ruthenium(II)-Catalyzed Azide–Alkyne Cycloaddition
por: Taguchi, Ryoichi, et al.
Publicado: (2023)

Synthesis of N-perfluoroalkyl-3,4-disubstituted pyrroles by rhodium-catalyzed transannulation of N-fluoroalkyl-1,2,3-triazoles with terminal alkynes
por: Bakhanovich, Olga, et al.
Publicado: (2021)

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor
por: Meuser, Megan E., et al.
Publicado: (2019)

4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth
por: Panda, Subhankar, et al.
Publicado: (2019)

Synthesis, Structural Investigations, DNA/BSA Interactions, Molecular Docking Studies, and Anticancer Activity of a New 1,4-Disubstituted 1,2,3-Triazole Derivative
por: Göktürk, Tolga, et al.
Publicado: (2023)

Proliferation, Migration and Invasion of Breast Cancer Cell Lines Are Inhibited by 1,5-Disubstituted Tetrazol-1,2,3-triazole Hybrids through Interaction with p53
por: Moreno-Perea, Marisol, et al.
Publicado: (2023)

Tyrosol Derivatives, Bearing 3,5-Disubstituted Isoxazole and 1,4-Disubstituted Triazole, as Potential Antileukemia Agents by Promoting Apoptosis
por: Abdelkafi-Koubaa, Zaineb, et al.
Publicado: (2022)

A Simple Work-Up-free, Solvent-free Approach to Novel Amino Acid Linked 1,4-Disubstituted 1,2,3-Triazoles as Potent Antituberculosis Agents
por: Garg, Anirban, et al.
Publicado: (2020)

Synthesis of a novel resorcin[4]arene–glucose conjugate and its catalysis of the CuAAC reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles in water
por: Husain, Ali A., et al.
Publicado: (2019)

1,2,3-Triazoles as Biomimetics in Peptide Science
por: Agouram, Naima, et al.
Publicado: (2021)

A One-Pot Six-Component Reaction for the Synthesis of 1,5-Disubstituted Tetrazol-1,2,3-Triazole Hybrids and Their Cytotoxic Activity against the MCF-7 Cell Line
por: Aguilar-Morales, Cesia M., et al.
Publicado: (2021)

Regioselective Reduction of 1H-1,2,3-Triazole Diesters
por: Butler, Christopher R., et al.
Publicado: (2021)

Macroporous polymer supported azide and nanocopper (I): efficient and reusable reagent and catalyst for multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from benzyl halides
por: Keshavarz, Mosadegh, et al.
Publicado: (2013)

Design, synthesis, conformational analysis, and biological activity of Cα(1)-to-Cα(6) 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues
por: Nuti, Francesca, et al.
Publicado: (2023)

Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles
por: Banday, Abid H, et al.
Publicado: (2012)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mgf064vqkbs88fcpn26kl427ab